Molecular Mechanisms of Biosignalling Transduction and Response via Secondary Metabolisms

由次级代谢产生的生物信号分子在个体生物体内稳态调节和它们之间的变态反应相互作用中起着重要作用。这些生物信号分子在活性位点的转导和应答仍然是模糊的，它们的分子机制应该迫切地被研究，以建立生命科学领域未来进展的下一阶段。通过次级代谢进行生物信号传导和响应的分子机制”，致力于生物化学领域以及与生物信号分子相关的生物化学领域的农业化学家们通过各自理论和实验积累的背景进行了讨论，解释了其分子机制。第一次讨论会于6月18日至19日举行，1996年在京都。第二次是1996年10月14日在仙台，第三次是1997年1月25日在名古屋，第四次是1997年1月28日在仙台。作为这些讨论的结果，得出的结论是，该项目的研究人员建议从1998年开始对题为“通过次级代谢调控和信号转导的分子机制”的优先领域的科学研究提供资助，申请表由首席研究员（包括从事生物合成相关研究的研究员）准备和提出。次级代谢产物

Biosignalling molecules produced by secondary metabolisms play substantial roles for both homeostastic regulations in individual organisms and alleropathetic interactions between them.However, biosyntheses, transduction and response in active sites of these biosignalling molecules are still ambiguous and their molecular mechanisms should be urgently investigated to establish the next stage for the future progress in the field of life science.In this project titled "Molecular Mechanisms of Biosignalling Transduction and Response via Secondary Metabolisms", the agricultural chemists who have devoted themselves in the field of origanic chemistry as well as biochemistry related to the biosignalling molecules discussed to explain their molecular mechanisms through their own theoretically and experimentally accumulated backgrounds.The Ist discussion meeting was held from June 18 to 19,1996 in Kyoto. The 2nd one on october 14,1996 in Sendai, the 3rd one on January 25,1997 in Nagoya and the 4th one on January 28,1997 in Sendai. As the result of these discussions, it was concluded that Grant-in Aid for Scientific Research on Priority Areas titled on "Molecular Mechanism on Regulations and Signal Transductions via Secondary Metabolites" was proposed to start from 1998 by the investigator members of this project, and the application form was prepared and proposed by the head investigator including investigators who are engaged in the research related to biosynthesis of secondary metabolites.