Chemical Studies on Mycoalexin Produced by Fungi

本课题源于我们对真菌孢子萌发的基础化学研究。一些真菌的孢子已被证明含有内源性自我抑制剂，其中一些在本项目中被表征。其他重要的结果是通过对长期在逆境条件下培养的真菌的行为进行详细观察而获得的，这些条件包括营养缺乏、高温、重金属的添加和其他真菌的污染。在这种条件下，某些种类的真菌产生真正的代谢物，暂时称为霉菌alexins，这似乎是控制其自身生命周期的必要因素。结果总结如下：1。对锈菌和炭疽病真菌孢子萌发自抑制剂的结构进行了表征。通过合成研究了这些自抑制剂的构效关系。研究了一株黑曲霉霉毒素的结构。从两株双色双星菌中分离出新的抗生素和植物毒性代谢物。并对其结构进行了表征。建立了一种检测霉菌alexin的新方法。

This project is originated from our basic chemical studies on fungal spore germination. Spores of a few fungi have been demonstrated to contain endogenous self-inhibitors, some of which were characterized in this project. Other important results were obtained by detailed observations on the behaviour of fungi which were cultivated for a long period under stressed conditions, such as deficiency of nutrients, higher temperature, addition of heavy metals and contamination of other mycroorganisms. In such conditions, some species of fungi produce genuine metabolites, tentatively termed mycoalexins, which seem to be an essential factor related to control their own life cycles. Summary of the results runs as follows :1. Structure of spore germination self-inhibitors from rust fungi and anthracnose fungi were characterized. The structure-activity relationship of the self-inhibitors were investigated by synthetic work.2. Structure of Mycoalexin from a Strain of Aspergillus Niger was Proposed.3. New type of antibiotic and phytotoxdic metabolites were isolated from two strains of Bipolaris bicolor. Their structures were also characterized.4. A new bioassay method has been developed for the detection of mycoalexin.