Development of mental and physical biomarkers and assessment of its usefulness

为了在一般人群中开发精神和身体生物标志物，我们测量和评估了精神和身体健康状况、外周血淋巴细胞的自然杀伤（NK）细胞活性、血清总IgE水平、血液淋巴细胞中的染色体改变和氧化损伤（8 OHdG）、尿诱变活性、唾液皮质醇和伊加水平的有用性，研究对象为1995年1月坂神淡路大地震中的男性成年人。生活方式和创伤后应激障碍（PTSD）评分与NK细胞活性有关。同样，血浆皮质醇水平与日本气象厅（JMA）地震强度有关。一般健康问卷（GHQ）评分也与地震强度有关。在日本成年男性工人中，唾液皮质醇水平与主观应激水平有关。在相同的主题，唾液伊加水平也与主观stresslevel.These观察表明，神经和免疫生物标志物在本研究中使用的健康受试者的健康状况的评估将是有用的，并可用于预测指标不希望的结果。

In order to develop mental and physical biomarkers in a general population, we measured and evaluated usefulness of mental and physical health status, natural killer (NK) cell activity of peripheral blood lymphocytes, serum total IgE levels, chromosome alterations and oxidative damage (8OHdG) in blood lymphocytes, urinary mutagenic activity, salivary cortisol and IgA levels, and genotypes closely related to lifestyles such as the ALDH2 genotype.Male adults who suffered from Hanshin-Awaji Earthquake in Jan. 1995 were enrolled in the studies. Both lifestyles and post traumatic stress disorder (PTSD) score were related to NK cell activity. Likewise, plasma cortisol levels were linked with Japan Meteological Agency (JMA) Intensity of the earthquake. General Health Questionnaire (GHQ) score was also related with the intensity of the earthquake.In Japanese male adult workers, salivary cortisol levels were related with subjective stress levels. In the same subjects, salivary IgA levels were also associated with subjective stress levels.These observations indicate that the neurological and immunological biomarkers used in the present studies would be useful in the assessment of health status of healthy subjects and can be used as predictive indices for undesired outcomes.