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Development of mental and physical biomarkers and assessment of its usefulness

精神和身体生物标志物的开发及其有用性评估

基本信息

批准号：
08407013
负责人：
MORIMOTO Kanehisa
金额：
$ 10.88万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08407013/
关键词：
lifestyle earthquake stress post traumatic stress disorder natural killer cell activity ALDH2 IgA cortisol ナチュラルオラー活性 PTSD NK細胞活性唾液尿中変異原活性アセトアルデヒド緑茶飲酒

项目摘要

In order to develop mental and physical biomarkers in a general population, we measured and evaluated usefulness of mental and physical health status, natural killer (NK) cell activity of peripheral blood lymphocytes, serum total IgE levels, chromosome alterations and oxidative damage (8OHdG) in blood lymphocytes, urinary mutagenic activity, salivary cortisol and IgA levels, and genotypes closely related to lifestyles such as the ALDH2 genotype.Male adults who suffered from Hanshin-Awaji Earthquake in Jan. 1995 were enrolled in the studies. Both lifestyles and post traumatic stress disorder (PTSD) score were related to NK cell activity. Likewise, plasma cortisol levels were linked with Japan Meteological Agency (JMA) Intensity of the earthquake. General Health Questionnaire (GHQ) score was also related with the intensity of the earthquake.In Japanese male adult workers, salivary cortisol levels were related with subjective stress levels. In the same subjects, salivary IgA levels were also associated with subjective stress levels.These observations indicate that the neurological and immunological biomarkers used in the present studies would be useful in the assessment of health status of healthy subjects and can be used as predictive indices for undesired outcomes.

为了开发一般人群的精神和身体生物标志物，我们测量和评估了精神和身体健康状况、外周血淋巴细胞的自然杀伤（NK）细胞活性、血清总IgE水平、血液淋巴细胞中的染色体改变和氧化损伤（8OHdG）、尿液诱变活性、唾液皮质醇和IgA水平以及与疾病密切相关的基因型的有用性。生活方式，如 ALDH2 基因型。 1995 年 1 月遭受阪神淡路地震的男性成年人被纳入研究。生活方式和创伤后应激障碍 (PTSD) 评分均与 NK 细胞活性相关。同样，血浆皮质醇水平与日本气象厅 (JMA) 地震强度有关。一般健康问卷（GHQ）评分也与地震烈度有关。在日本男性成年工人中，唾液皮质醇水平与主观压力水平有关。在同一受试者中，唾液 IgA 水平也与主观压力水平相关。这些观察结果表明，本研究中使用的神经学和免疫学生物标志物将有助于评估健康受试者的健康状况，并可用作不良结果的预测指标。