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Sociomedical-informative study on establishment of supporting model of health behavior changes

建立健康行为改变支持模型的社会医学信息研究

基本信息

批准号：
14207017
负责人：
MORIMOTO Kanehisa
金额：
$ 27.71万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14207017/
关键词：
Lifestyle Natural killer cell activity Chromosome aberration Stress Cortisol Brain science Aging Preventive medicine クロモグラニンA ストレスホルモンコーチゾール健康年令

项目摘要

The total environments to which individuals have been exposed throughout the lifestages from birth to the present time have been composing the individual and community lifestyles, or ways of daily living. Such lifestyles are known to determine the risks for development of cancers, circulatory diseases, and other chronic diseases. To establish new theory and practice programs for disease prevention and health promotion in the environmental medicine, we have quantitatively investigated correlations of lifestyle to comprehensive health potentials. The health potentials were assessed by both the ridit and multiphasic analysis of general health-check-up data, and the measurements of typical biomarkers such as lymphocyte chromosome alterations, natural-killer cell activities, and serum IgE levels.The general health status was assessed by the ridit analysis of the incidence of abnormal values in blood-biochemistry, blood-pressure, and urine tests of multiphasic health check-ups. The general health was found to decrease with aging, but to vary a lot according to their lifestyles. For example, the mean level of somatic health of the persons having poor lifestyles in the 20's was about the same that of those with good lifestyles in the 40's. According to the results of follow-up of workers, the unhealthy workers were found to have had significantly higher risks for the developments of chronic diseases such as heart attack, liver disease, and diabetes.

个人从出生到现在的整个生命阶段所接触的总体环境构成了个人和社区的生活方式或日常生活方式。众所周知，这种生活方式决定了患癌症、循环系统疾病和其他慢性病的风险。为建立环境医学疾病预防和健康促进的新理论和实践方案，我们定量研究了生活方式与综合健康潜力的相关性。通过对一般健康检查资料进行Ridit分析和多相分析，以及淋巴细胞染色体变异、自然杀伤细胞活性、血清IgE水平等典型生物标志物的测定，评价健康潜力;通过对多相健康检查中血生化、血压、尿检异常值的发生率进行Ridit分析，评价一般健康状况。一般健康被发现随着年龄的增长而下降，但根据他们的生活方式有很大的不同。例如，20年代生活方式不良的人的平均身体健康水平与40年代生活方式良好的人的平均身体健康水平大致相同。根据对工人的随访结果，发现不健康的工人患心脏病、肝病和糖尿病等慢性病的风险明显较高。