Correlations between Lefestyles and Mental- or Physical Health Status

生活方式与心理或身体健康状况之间的相关性

• 批准号: 02404034
• 负责人: MORIMOTO Kanehisa
• 金额: $ 1.47万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404034/
• 关键词: lifestyle; QOL; health status; chromosome aberration; sister chromatid exchange; aldehyde dehydrogenase; allergy; natural killer cell activity; ライフスタイル; 性格; 染色体変異; アルデヒド脱水素酵素; Natural Killer活性; 健康維持要因; ストレス量; エゴグラム; 精神的健康; 姉妹染色分体交換(SCE) /

1. In Japanese workers, lifestyles such as smoking. drinking, self-reported stress, physical exercise, mental health status including character and quality of life, and physical health status were comprehensively measured using questionnaires and physical examination data.2. In the same subjects, frequencies of sister-chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes were measured. Those who have good lifestyles had lower frequencies of SCE and lower enhancement ratios of CA frequencies by ara-C, compared to those with poor lifestyles. Genotypes of low Km ALDH2 were determined by the PCR method. Habitual drinkers who lack ALDH2 had significantly higher SCE frequency than non-habitual drinkers who lack ALDH2 or those who possess ALDH2 activity. Generally, alcohol-drinking bahaviors were strongly regulated by the ALDH2 activity.3. Natural killer (NK) activities were significantly higher in those with good lifestyles than those with poor lifestyles. Proportions of subsets of lymphocytes were also correlated with good lifestyles.4. Higher total IgE levels were significantly correlated with lifestyles, especially with smoking, and alcohol consumption.

1. 日本工人的生活方式，如吸烟。采用问卷和体检数据综合测量饮酒、自述压力、体育锻炼、性格和生活质量等心理健康状况、身体健康状况。 2．在同一受试者中，测量了外周淋巴细胞中姐妹染色单体交换（SCE）和染色体畸变（CA）的频率。与生活方式不良的人相比，生活方式良好的人 SCE 频率较低，ara-C 对 CA 频率的增强率也较低。采用PCR方法测定低Km ALDH2基因型。缺乏 ALDH2 的习惯性饮酒者的 SCE 频率显着高于缺乏 ALDH2 的非习惯性饮酒者或具有 ALDH2 活性的人。一般来说，饮酒行为受到ALDH2活性的强烈调节。3．生活方式良好的人的自然杀伤（NK）活性显着高于生活方式不良的人。淋巴细胞亚群的比例也与良好的生活方式相关。4．较高的总 IgE 水平与生活方式显着相关，尤其是与吸烟和饮酒有关。

项目成果

Takeshita,T.et al.: "Phenotypic clifferences in low km aldehyde dehydrogenase.in Japanese.workers" Lancet. 341. 837-838 (1993)

Takeshita,T.et al.：“日本工人中低 km 醛脱氢酶的表型悬崖”《柳叶刀》。

Hagihara, A., Kusaka, Y., Morimoto, K., Tamura, T. and Matsuura, Y.: "Health risk appraisal (HRA) and its educational effects on bank employees." Industrial Health. 30. 61-64 (1992)

Hagihara, A.、Kusaka, Y.、Morimoto, K.、Tamura, T. 和 Matsuura, Y.：“健康风险评估 (HRA) 及其对银行员工的教育影响。”

Morimoto, K.: Springer-Verlag, Berlin. Life-style and genetic factors that determine the susceptibility to production of chromosome damage. in ed. by Obe, G., Natarajan, A. T.: Chromosomal aberrations. Basic and applied aspects., 287-301 (1990)

Morimoto, K.：施普林格出版社，柏林。

森本 兼曩: "ライフスタイルと健康" 医学書院, 330 (1991)

森本兼弘：《生活方式与健康》医学书院，330（1991）

Iijima,K.,Morimoto,K.: "Quantitative analyses of the induction of chromosome aberrations and sister chromatid exchanges in human lymphocytes exposed to γーrays and MitomycinーC in combination" Mutation Res.263. 263-268 (1991)

Iijima, K., Morimoto, K.：“暴露于 γ 射线和丝裂霉素 C 组合的人类淋巴细胞中染色体畸变和姐妹染色单体交换诱导的定量分析”突变研究 263. 263-268 (1991)