Synthesis and Application of Highly Coordinated Nitrogen-Ligands

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1) Highly coordinated nitrogen-ligands were synthesized to be applied to asymmetric catalytic cylcopropanation of olefins with ruthenium catalysis. The intermediate carbene complexes were determined by NMR and X-ray analysis, and its geometry and moleculer orbitals were considered.2) Single chiral version of nitrogen-ligand were discovered and applied to asymmetric cyclopropanation to give high enantioselectivity.3) Chiral oxazoline ligand designed in this research exhibited high efficiency in asymmetric cylcopropanation over 80% ees.4) New nitrogen-benzene ligands were developed for asymmetric catalysis. One of them exhibited high efficiency in asymmetric allylation of aldehydes, and the catalyst proved to be recovered for reuse.