权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Evaluation of significant dermal absorption on organic solvent vapor.

评估皮肤对有机溶剂蒸气的显着吸收。

基本信息

批准号：
08457119
负责人：
SAKURAI Haruhiko
金额：
$ 5.5万
依托单位：
National Institute of Industrial Health (1997)Keio University (1996)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

项目摘要

Aim We investigated the potential for dermal absorption of N,N-Dimethylacetamide (DMAC : CAS No. 127-19-5) or N,N-Dimethylformamide (DMF : CAS No.67-12-2) vapor, the biological half-life of N-Methylacetamide (NMAC) in urine or of N-Methylformamide (MNF) in urine which were major matabolites of DMAC or DMF respectively.Method Twelve male Japanese healthy volunteers were exposed to DMAC or DMF vapor by inhalation and dermal exposures, exposed about 90% naked skin area without sweating, respectively for 4 hours at concentrations set below 10 ppm that was recommended as Occupational Exposure Limit by Japanese Society of Occupational Health and ACGIH.Dermal absorption was compared to absorption by inhalation exposure by the comparison with total excreted urinary metabolites' volume. All volunteers were checked their conditions before and during exposures and in 3 or 4 days after exposures by medical examinations and blld and urine examinations.Results All exposures were conducted under 10 ppm. Exposure levels were 6.00 (]SY.+-。[) 1.00 ppm by inhalation and 6.00 (]SY.+-。[) 1.00 ppm by dermal exposures in DMAC experimental study and 6.00 (]SY.+-。[) 1.00 ppm by inhalation and 6.00 (]SY.+-。[) 1.00 ppm by dermal exposures in DMF experimental study on the conditions around 26ﾟC and 40% relative humidity. Absorption ratio determined were 40 : 60 or 42.5 : 57.5 in DMAC or DMF experimental studies respectively.Conclusion Over 40% dermal absorption vs the absorption by inhalation of DMAC or DMF vapor were performed. It seems necessaty to care a concentration of workplace in order to protect dermal absorption as well as a care to DMAC or DMF liquid.

目的我们研究了 N,N-二甲基乙酰胺（DMAC：CAS 号 127-19-5）或 N,N-二甲基甲酰胺（DMF：CAS 号 67-12-2）蒸气的皮肤吸收潜力、尿液中 N-甲基乙酰胺（NMAC）或尿液中 N-甲基甲酰胺（MNF）的生物半衰期（DMAC 的主要代谢物）方法 12 名日本男性健康志愿者通过吸入和皮肤暴露方式暴露于 DMAC 或 DMF 蒸气，分别在不出汗的情况下暴露约 90% 裸露皮肤面积 4 小时，浓度设定为低于日本职业健康协会和 ACGIH 推荐的职业暴露限值 10 ppm。与尿代谢物总排泄量的比较。所有志愿者在暴露前、暴露期间以及暴露后3或4天内均通过医学检查以及血液和尿液检查检查其状况。结果所有暴露均在10 ppm以下进行。在 DMAC 实验研究中，暴露水平为 6.00 (]SY.+-。[) 1.00 ppm（吸入）和 6.00 (]SY.+-。[) 1.00 ppm（皮肤暴露）；在 DMAC 实验研究中，暴露水平为 6.00 (]SY.+-。[) 1.00 ppm（吸入）和 6.00 (]SY.+-。[) 1.00 ppm（皮肤暴露）。 DMF周围条件实验研究 26°C 和 40% 相对湿度。在DMAC或DMF实验研究中测定的吸收比分别为40:60或42.5:57.5。结论与吸入DMAC或DMF蒸气的吸收相比，进行了超过40%的皮肤吸收。为了保护皮肤的吸收，需要注意工作场所的浓度以及对DMAC或DMF液体的护理。