Development of Implant Biomaterials by Ceramic Coating Technologies

我们已经开发了一些陶瓷涂层技术，主要是电泳沉积（EPD），溅射（SP）和等离子喷涂（PS）的方法进行植入生物材料。我们的新EPD方法成功地制备了复合涂层，包括粘附层的磷灰石-磷酸钙和生物活性多孔表面的磷灰石-石墨。在SPT方法中，我们建立了使用具有比羟基磷灰石低的Ca/P比的磷酸钙玻璃靶。该方法也被应用于通过水热退火的金属基底的涂覆。使用羟基磷灰石和磷酸三钙的PS膜，两者之间的生物相容性进行了评价，通过细胞培养，表明后者似乎在某种程度上优于后者，因为可溶性。我们还研究了在这些薄膜上的极化辅助类骨晶体生长。

We have developed implant biomaterials by some ceramic coating technologies, which were mainly undertaken by electrophoretic deposition (EPD) , sputtering (SP) , and plasma spray (PS) methods. Our new EPD method successfully produced composite coatings, consisting of the layrs of adhersive apatite-calcium phosphate and bioactive porous surface of apatite-graphite. In SPT method, we established the use of glass targets of calcium phosphates with lower Ca/P ratios than hydroxyapatite. This method was also applied to the coating of metal substrates by hydrothermal annealing. Using PS films of hydroxyapatite and tri-calcium phosphate, the biocompatibility between the two was evaluated by cell cultivation, suggesting the latter seems somehow excellent to the latter because of the solbility. We also studied the poling-aided bone-like crystal growth on these films.