エストロゲン活性を有する内分泌撹乱化学物質類の学習記憶能に及ぼす影響評価
エストロゲン活性を有する内分泌撹乱化学物質類の学習記憶能に及ぼす影響評価
批准号:
22510069
负责人:
YAMASHITA Kimihiro
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We investigated the effects of perinatal exposure to bisphenol A (BPA), nonylphenol (NP) and genistein (GNS) on learning and memory function, general activities and emotionality in male SD offspring rats, using a battery of behavioral tests. Perinatal exposure to NP and GNS specifically improved, but low-dose BPA specifically impaired spatial learning and memory in male offspring rats. These results suggest that the effects to estrogenic endocrine disruptors on learning and memory function correlate to their estrogenic activities.
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ビスフェノールA周産期曝露が雄性ラットの学習記憶に及ぼす影響
围产期接触双酚A对雄性大鼠学习记忆的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[安田佳代, 石井直明 他, 山下樹三裕]
通讯作者:
山下樹三裕
ビスフェノールAの海馬内微量注入が雌性ラットの学習記憶に及ぼす影響についての研究
海马微量注射双酚A对雌性大鼠学习记忆影响的研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[安田佳代, 石井直明 他, 山下樹三裕, 山下樹三裕]
通讯作者:
山下樹三裕
トリブチルスズのラット学習記憶に及ぼす影響評価
三丁基锡对大鼠学习记忆的影响评价
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tsurusaki T., Sakakibara H., Aoshima Y., Yamazaki S., Sakono M. and Shimoi K., 山下樹三裕]
通讯作者:
山下樹三裕
Effects of perinatal exposure to nonlphenol on the function of central nervous system in male rat offsprings
围产期非苯酚暴露对雄性大鼠子代中枢神经系统功能的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[上山純, 伊藤牧, 齋藤勲, 高木健次, 近藤高明, 涌澤伸哉, 仲井邦彦, 佐藤洋, 上島通浩, Kimihiro Yamashita]
通讯作者:
Kimihiro Yamashita
Effects of perinatal exposure to nonylphenol on the function of central nervous system in male rat offsprings
围产期壬基酚暴露对雄性大鼠子代中枢神经系统功能的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Tsurusaki T., Sakakibara H., Aoshima Y., Yamazaki S., Sakono M. and Shimoi K., Kimihiro Yamashita]
通讯作者:
Kimihiro Yamashita
共 9 条
Fundamental and developmental reseaches of polarized ceramic biomaterials to accelerate the tissue regenerations
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批准号:23300178
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.81万
-
财政年份:2011
-
负责人:YAMASHITA Kimihiro
-
依托单位:
Efficient induction and maintenance in vivo of tumor antigen specificCD4+ T cells in cancer immunotherapy
-
批准号:22591487
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.41万
-
财政年份:2010
-
负责人:YAMASHITA Kimihiro
-
依托单位:
Effects of environmental endocrine disrupters on learning, memory and emotional behavior in the function of central nervous system
-
批准号:12836011
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.62万
-
财政年份:2000
-
负责人:YAMASHITA Kimihiro
-
依托单位:
Effects of environmental stresses on the permeability of blood brain barrier
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批准号:10680519
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:1998
-
负责人:YAMASHITA Kimihiro
-
依托单位:
Analysis and Biomedical Material Applications of Biological Hard Tissue Formation Based on Electromagnetics
-
批准号:10305047
-
项目类别:Grant-in-Aid for Scientific Research (A).
-
资助金额:$19.65万
-
财政年份:1998
-
负责人:YAMASHITA Kimihiro
-
依托单位:
A research to the participation of endotheline-nitric oxide system in pathophysiology of ischemic disorder of a small intestine and a development for its therapeutic usage.
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批准号:08672616
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
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财政年份:1996
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负责人:YAMASHITA Kimihiro
-
依托单位:
Development of Implant Biomaterials by Ceramic Coating Technologies
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批准号:08555219
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$8.26万
-
财政年份:1996
-
负责人:YAMASHITA Kimihiro
-
依托单位:
Synthesis, Strucure and Properties of Rare Earth Oxide-Containing Silico phosphate Glasses and Glass Seramics
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批准号:07455350
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.74万
-
财政年份:1995
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负责人:YAMASHITA Kimihiro
-
依托单位:
海外基金