DEVELOPMENT OF RE-ENTRANT TYPE RESONANT CAVITY APPLICATOR FOR DEEP TUMOR HYPERTHERMIA

凹入式谐振腔深部肿瘤热疗治疗仪的研制

• 批准号: 08557056
• 负责人: MATSUDA Jin-ichi
• 金额: $ 5.25万
• 依托单位: NAGAOKA UNIVERSITY OF TECHNOLOGY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08557056/
• 关键词: hyperthermia; deep heating; re-entrant type resonant cavity; resonant frequency; impedance matching; computer control; agar phantom; animal experiment; コンピュータ・シミュレーション; 人体等価ファントム

In this research project, a new heating system using a re-entrant resonant type cavity applicator for deep-seated tumor hyperthermia treatment is proposed. The developed heating system consists of a re-entrant type resonant cavity made of an aluminum alloy, an RF (radio frequency) amplifier, a power supply unit, a matching unit, and a microcomputer. To verify the possibility of this heating system for deep-seated tumor, the following three experiments using cylindrical phantoms and dogs were perfomed :(1) The agar phantom used in this experiment was 27.0cm in diameter and 25.0cm high. Heating pattems were observed with a thermographic camera. The thermal image of the vertical sectional slice of the agar phantom clearly showed that the center region of the phantom was heated concentrically, as expected.(2) The three layred lard agar phantom was used in the experiment. The agar phantom, wich 20.0cm in thickness, was sandwiched between the two lard-disk layrs, which were 2.0cm and 1.5cm in thickness respectively. Although small hot spots, due to the edge effect, appeared in the lard layrs, maximum temperature still appeared at the center region of the phantom.(3) The final experiment was to heat the liver and brain of a beagle dog. Fiber optic temperature sensors were placed at four points in the dog's tissue. Against much blood perfusion in these tissues, the measured temperatures at the deepest region was 0.5-0.7ﾟC higher than the other regions of the tissue.From these experimental heating results, it is confirmed that the system can be applicable to both local and deep tumor hypethermia.

在本研究计画中，我们提出一种新的加热系统，使用一个可重入式共振型腔体加热器来进行深部肿瘤热疗。所开发的加热系统包括由铝合金制成的凹进型谐振腔、RF（射频）放大器、电源单元、匹配单元和微计算机。为验证该系统用于深部肿瘤加热的可行性，用圆柱形体模和狗进行了以下三个实验：（1）实验用的琼脂体模直径27.0cm，高25.0cm。用热像照相机观察加热模式。琼脂体模的垂直截面切片的热图像清楚地显示，体模的中心区域被同心加热，正如预期的那样。(2)实验采用三层猪油琼脂模体。将20.0cm厚的琼脂模体夹在2.0cm厚和1.5cm厚的两层厚的圆盘之间。虽然由于边缘效应，在猪油层中出现了小的热点，但最高温度仍然出现在体模的中心区域。(3)最后一个实验是加热一只小猎犬的肝脏和大脑。光纤温度传感器被放置在狗的组织中的四个点。实验结果表明，该系统不仅适用于肿瘤局部热疗，而且适用于肿瘤深部热疗。

项目成果

Kazuo Kato, Jin-ichi Matsude, Takeo Uzuka, Hideaki Takahashi, Ryuichi Tanaka: "An Experiment of Heating Using the Re-entrant Type Resonant Cavity Heating System in Dogs" Hyperthermic Oncology in Japan '97. 119-120 (1997)

Kazuo Kato、Jin-ichi Matsude、Takeo Uzuka、Hideaki Takahashi、Ryuichi Tanaka：“使用凹入式谐振腔加热系统对狗进行加热的实验”日本热肿瘤学 97。

Kazuo Kato, Eiji Kasai, Jin-ichi Matsuda,: "A Study of Re-entrant Type Resonant Cavity Applicator for Deep Tumor Hyperthermia" Proc.of the 7th International Congress on Hyperthermic Oncology. Vol.II. 473-475 (1996)

Kazuo Kato、Eiji Kasai、Jin-ichi Matsuda，“用于深部肿瘤热疗的再入式谐振腔施用器的研究”第七届国际热肿瘤学大会论文集。

Kazuo Kato, Eiji Kasai、Jin-ichi Matsuda: "A Study of Re-entrant Type Resonant Cavity Application for Deep Tumor Hyperthermia" Proc.of the 7th International Congress on Hyperthermic Oncology. Vol.II. 473-475 (1996)

Kazuo Kato、Eiji Kasai、Jin-ichi Matsuda：“用于深部肿瘤热疗的凹入式谐振腔应用的研究”，第七届国际热肿瘤学大会论文集，第 473-475 卷（1996 年）。

加藤和夫、中平好則、松田甚一: "大型リエントラント型加温装置による加温基礎実験" The Journal of the Japanese Society of Thermology. Vol.17,No.1. 8-10 (1997)

Kazuo Kato、Yoshinori Nakahira、Jinichi Matsuda：“使用大型折返加热装置的基本加热实验”日本热学会杂志第 17 卷，第 1 期（1997 年）。

Jin-ichi Matsuda, Kazuo Kato、Takashi Nishimachi, Eiji Kasai: "Analysis of Heating Properties of the Re-entrant Type Resonant Cavity Applicator by Computer Simulation" Hyperthermic Oncology in Japan '96. 112-113 (1996)

Jin-ichi Matsuda、Kazuo Kato、Takashi Nishimachi、Eiji Kasai：“通过计算机模拟分析凹口型谐振腔涂抹器的加热特性”日本热肿瘤学 96 (1996)。