Systems-level characterization of scaffold protein signalling networks

支架蛋白信号网络的系统级表征

• 批准号: DP220103638
• 负责人: Prof Roger Daly
• 金额: $ 43.3万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-05-19 至 2025-05-18
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103638
• 关键词: Systems; level; characterization; scaffold; protein

The PEAK family of cell signalling scaffolds regulate cellular responses critical for normal development and physiology. This project will adopt a ‘holistic’ approach to characterizing their mechanism and function, integrating experimental and mathematical approaches and developing predictive computational models. It aims to generate fundamental new knowledge in cell, computational and synthetic biology with broad relevance that will foster establishment of new international linkages. This research will also identify strategies for engineering novel scaffolds that re-program cellular behaviour towards specific, applied outcomes, with potential benefit for the fields of synthetic biology, bioengineering and biotechnology.

细胞信号传导支架的PEAK家族调节对正常发育和生理至关重要的细胞反应。该项目将采用“整体”方法来表征其机制和功能，整合实验和数学方法，并开发预测计算模型。它旨在产生细胞、计算和合成生物学方面的基本新知识，这些知识具有广泛的相关性，将促进建立新的国际联系。这项研究还将确定工程新型支架的策略，这些支架将细胞行为重新编程为特定的应用结果，对合成生物学，生物工程和生物技术领域具有潜在的益处。