Dynamic regulation of cell signalling scaffolds

细胞信号支架的动态调控

• 批准号: DP190103672
• 负责人: Prof Roger Daly
• 金额: $ 34.13万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-04-30 至 2022-04-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103672
• 关键词: Dynamic; regulation; cell; signalling; scaffolds

This project aims to determine how cells utilise scaffold-type signalling proteins to orchestrate, over time, diverse cellular responses critical for normal development and physiology. The project expects to generate fundamental new knowledge in cell and synthetic biology with broad relevance that will foster establishment of new international linkages and networks. This research should benefit the biotechnology sector by identifying strategies for engineering scaffolds with desired biological outputs, with applications in areas such as large-scale cell production, immunotherapy, wound healing and regenerative medicine.

该项目旨在确定细胞如何利用支架型信号蛋白来协调，随着时间的推移，对正常发育和生理至关重要的多种细胞反应。该项目预计将产生具有广泛相关性的细胞和合成生物学基础新知识，这将促进建立新的国际联系和网络。这项研究应通过确定具有所需生物产出的工程支架的战略，使生物技术部门受益，并应用于大规模细胞生产，免疫治疗，伤口愈合和再生医学等领域。