Characterization of SgK269, a master regulator of growth factor receptor signalling

生长因子受体信号传导的主调节因子 SgK269 的表征

• 批准号: nhmrc : 1084621
• 负责人: Prof Roger Daly
• 金额: $ 41.59万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterization-sgk269-master-receptor-signalling/519019
• 关键词: Characterization; SgK269; master; regulator; growth

Perturbed signaling within a cell can cause multiple diseases, including cancer. SgK269 is a scaffold protein involved in signaling and implicated in breast, colon and pancreatic cancer. By determining the signaling mechanism and function of the SgK269 scaffold, this work will provide novel and important insights into a key regulator of cell signaling, and reveal potential strategies for therapeutic targeting of the SgK269 scaffold that could be utilized in cancer treatment.

细胞内的信号紊乱会导致多种疾病，包括癌症。SgK269是一种参与信号传导的支架蛋白，与乳腺癌、结肠癌和胰腺癌有关。通过确定SgK269支架的信号传导机制和功能，这项工作将为细胞信号传导的关键调节因子提供新的和重要的见解，并揭示可能用于癌症治疗的SgK269支架的治疗靶向策略。