Identification of novel treatment strategies for human cancers through integrative phosphoproteomics and kinomics.

通过综合磷酸蛋白质组学和运动学鉴定人类癌症的新治疗策略。

• 批准号: nhmrc : 1058540
• 负责人: Prof Roger Daly
• 金额: $ 50.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-novel-treatment-phosphoproteomics-kinomics/454682
• 关键词: Identification; novel; treatment; strategies; human

This proposal aims to use new cutting-edge techniques to characterize, at a global level, changes in growth regulatory signals in cancer cells. This will identify proteins critical for cancer growth that represent potential targets for therapy. In addition it will highlight ways to select the most effective treatments for individual patients. The ultimate outcome of this work will be improved treatment strategies for cancer patients, and hence reduced morbidity and mortality.

该提案旨在使用新的尖端技术在全球范围内表征癌细胞生长调节信号的变化。这将确定对癌症生长至关重要的蛋白质，这些蛋白质代表了潜在的治疗靶点。此外，它还将强调为个体患者选择最有效治疗方法的方法。这项工作的最终成果将是改善癌症患者的治疗策略，从而降低发病率和死亡率。