Regulation of mitogenic signalling via the Gab2 docking protein

通过 Gab2 对接蛋白调节有丝分裂信号

• 批准号: nhmrc : 230814
• 负责人: Prof Roger Daly
• 金额: $ 9.45万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-mitogenic-signalling-docking-protein/95165
• 关键词: Regulation; mitogenic; signalling; via; Gab2

Cell proliferation is regulated by growth factors which bind to specific receptors on the cell surface. These receptors then transmit a signal to the interior of the cell instructing it to divide. Inside the cell, the signal is transmitted by signalling proteins. Importantly, aberrant signalling by growth factor receptors or intracellular signalling molecules can contribute to cancer. We have recently demonstrated that the signalling protein Gab2 is overexpressed in a subset of breast cancers. Furthermore, we have identified that another protein, termed PKB, can 'switch off' signalling by Gab2, and that deregulated signalling by Gab2 can make cells cancerous. The aim of this project is to characterize how PKB regulates Gab2, and to investigate whether this mechanism is impaired in human cancers, leading to enhanced Gab2 signalling. The research will provide important information regarding how growth factor signals are transmitted inside cells, and may identify a new cancer-causing gene.

细胞增殖受与细胞表面特异性受体结合的生长因子调节。然后这些受体将信号传递到细胞内部，指示细胞分裂。在细胞内，信号由信号蛋白传递。重要的是，生长因子受体或细胞内信号分子的异常信号传导可促成癌症。我们最近证明，信号蛋白Gab2在乳腺癌的一个子集中过表达。此外，我们已经确定了另一种称为PKB的蛋白质可以“关闭”Gab2的信号传导，并且Gab2的失调信号传导可以使细胞癌变。该项目的目的是表征PKB如何调节Gab2，并研究这种机制是否在人类癌症中受损，从而增强Gab2信号传导。这项研究将提供有关生长因子信号如何在细胞内传递的重要信息，并可能发现一种新的致癌基因。