クロム肺癌:20年目における疫学調査および遺伝子検索

铬肺癌：第20年的流行病学调查与基因检索

• 批准号: 08670230
• 负责人: 石川 雄一
• 金额: $ 1.47万
• 依托单位: Japanese Foundation For Cancer Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670230/
• 关键词: 肺癌; クロム酸塩; 疫学調査

クロム酸塩製造作業に従事した労働者には,肺癌が多発することが知られている.われわれは1975年10月以降,東京にあった工場(1975年8月まで操業)で働いていた男性従業員84名を対象に,肺癌の早期発見をめざして,胸部レントゲン撮影,喀痰細胞診で年2回の検診を開始した.レ線上異常陰影を見るか,あるいは細胞診でクラスIII以上が出た場合は,当施設の病院で気管支内視鏡検査,1980年以降はCTを加えた精査を行い,これまでに多くの肺癌を早期に発見・治療してきた.また,可能な限り剖検まで行なって,これまでに13例の剖検例を詳細に検索した.1995年は検診を開始してから20年が経過し,ごく軽度の曝露のみの症例を除き,大部分の症例の転帰が判明しうると考えられるので,再度の疫学調査およびこれまで集積した腫瘍組織を用いての遺伝子検索を行なった.今回は肺癌に絞ってその後の発がんを調査した.84名中,死亡者12人に計26この肺癌が発生した.12人中11人は剖検が行われており,全例,当施設で行われた.多重癌が多いのが特徴で,その内訳は,単発癌5例,2重癌5例,3重癌1例,8重癌1例であった.(この8重癌症例については,別途学会で発表した.)肺癌の組織型は,これまでの調査と同様で,扁平上皮癌が主であった.年齢・性別をマッチさせた一般人との比較による相対危険度の算出は現在進行中である.前回(1984年)の調査で16.6であったが,今回はそれを上回るものと推定される.遺伝子検索では,microsatellite markersを用いたp53遺伝子のLOHを4例の扁平上皮癌について検索したところ,100%(4/4)で認められた.このことは,一般の扁平上皮癌と同様,クロム肺癌でもp53癌抑制遺伝子が発がんに強く関与していることを意味している.現在,さらに症例数を増やすとともに,その他の染色体部位でもLOH検索を行っている.

The patients with lung cancer are suffering from lung cancer, and the patients with lung cancer are more likely to suffer from lung cancer. Since October 1975, a total of 84 male workers in Beijing (August 1975) have been enrolled in the hospital. In the early stage of lung cancer, they have been seen in the early stages of lung cancer, and they have been photographed in the chest. There is a lot of information on the line, and you can see that there is a problem in the treatment of lung cancer in the early stage of lung cancer in the early stage of lung cancer in 1980, when you are in the hospital, when you are in the hospital, in 1980, you have seen the treatment of lung cancer in the early stage. It is possible to limit the number of patients who have been admitted to the hospital, and 13 cases have been dissected. In 1995, after 20 years of treatment, it has been reported that the symptoms of the disease have been eliminated, and most of the cases have been diagnosed and diagnosed. Once again, the organization of the epidemic disease information collection will use the information system to make sure that the information is available. Of the 84 patients who died of lung cancer, 12 died of lung cancer. 11 of the 12 patients underwent surgical procedures. In all cases, the construction was performed. There were 5 cases of multiple cancers, 5 cases of secondary cancers, 1 case of triple carcinomas and 1 case of multiple cancers. There are 8 serious cases of cancer, but you should learn the table in other ways. The histological type of lung cancer is similar to that of flat epithelial carcinoma. In terms of age and gender, the average person compares the relative risk of each other and calculates the current level of crisis. Last time (1984), I was told that 16.6 days ago, and this time I did not know if I was presumed to be in trouble. Microsatellite markers was used in 4 cases of flat epithelial carcinoma, 4 cases of flat epithelial carcinoma. In general, flat epithelial carcinoma is the same as lung cancer, p53 cancer suppressant, p53 cancer suppressor, tumor suppressor. At present, the number of cases of the disease is much higher than that of the chromosomal part of the chromosome. The number of LOH cases is different.

项目成果

Ishikawa Y,ら: "Low rates of Paget disease of bone and osteosarcoma in elderly Japanese." Lancet. 347. 1559- (1996)

Ishikawa Y 等人：“日本老年人骨佩吉特病和骨肉瘤的发病率较低”，《柳叶刀》347。1559-（1996 年）

Yoshimura K.Fukui I,Ishikawa Y,ら: "Locally-confined signet-ring cell carcinoma of the prostate : a case report of a long-term survivor." IntJ Urol. 3. 406-7 (1996)

Yoshimura K. Fukui I, Ishikawa Y, et al.：“前列腺局部印戒细胞癌：长期幸存者的病例报告。IntJ Urol。”3. 406-7 (1996)

Goto M,Imamura Oら: "Analysis of helicase gene mutations in Japanese Werner's syndrome patients." Hum Genet. 99. 191-3 (1997)

Goto M、Imamura O 等人：“日本维尔纳综合征患者的解旋酶基因突变分析。”99. 191-3 (1997)

Matsumoto T,Imamura O,ら: "Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure : Genetic epidemiology in the Japanese population." Hum Genet (in press). (1997)

Matsumoto T、Imamura O 等人：“基于基因组结构的维尔纳综合征基因的突变和单倍型分析：日本人群的遗传流行病学”（出版中）。

Goto M,Miller RW,Ishikawa Yら: "Excess of rare cancers in Werner syndrome (adult progeria)" Cancer Epidemiol.Biomark.Prev.5. 239-246 (1996)

Goto M、Miller RW、Ishikawa Y 等人：“Werner 综合征（成人早衰症）中罕见癌症的发生”Cancer Epidemiol.Biomark.Prev.5 (1996)。