A follow-up study to assess prognostic factors for subjects with positive anti-HCV antibody.

一项评估抗 HCV 抗体阳性受试者预后因素的后续研究。

• 批准号: 08670437
• 负责人: MORI Mitsuru
• 金额: $ 1.34万
• 依托单位: Saga Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670437/
• 关键词: Anti-HCV antibody; Follow-up study; Hepatocellular carcinoma; Hepatic cirrhosis; Mortality; Risk factor; 危険因子

Purpose : We followed-up inhabitants in the area of high incidence of hepatocellular carcinoma (HCC) to assess their prognostic risk factors with special reference to anti-hepatitis C virus antibody (HCV) seropositivity.Methods : In June of 1992, a baseline survey, including HCV seropositivity, other serological tests, and several life-styles, was conducted for 3,575 inhabitants aged 30 years or over (1,150 males and 2,425 females) at K.Town of Saga Prefecture, where the age-adjusted incidence of HCC was reported as high as 47.2 and 10.2 per 10^5 population in 1987 for males and females ; respectively. A follow-up survey was performed from April to June of 1997.Hazard ratios (HRs) and their 95% confidence intervals of potential risk factors for mortality by all causes as well as for having newly diagnosed HCC were estimated with the Cox's proportional hazard model.Results : During the follow-up period, 73 males and 51 females died with various causes, and 12 males and 10 females were n … More ewly diagnosed as having HCC.The risk on mortality was significantly increased with age (trend, HR=2.76,2.28-3.35) and sex (male, HR=2.18,1.52-3.13). For males, the age-adjusted risks on mortality were Significantly increased with having HCC (HR=13.37,6.83-26.17), any other cancer (HR=5.80,3.56-9.46), liver cirrhosis (HR=8.07,4.23-15.37), HCV seropositivity (HR=2.38,1.42-3.99), and so on. For females, the age-adjusted risks on mortality were significantly increased with having any cancer other than HCC (HR=18.11,10.40-31.53), liver cirrhosis (HR=5.31,2.11-13.39), family history of liver diseases (HR=2.72,1.36-5.47), and so forth. For males, the age-adjusted risks on having HCC were significantly increased with HCV seropositivity (HR=74.56,9.60-579.32), cessation of alcoholic drinking (HR=4.82,1.27-18.24), family history of liver diseases (HR=3.83,1.03-14.23), and so on. For females, the age-adjusted risks on having HCC were significantly increased with HCV seropositivity (HR=29.09,5.60-151.09), cessation of alcoholic drinking (HR=24.22.3.06-191.66), and so forth. Less

目的：我们随访了肝癌高发区的居民，以评估其预后危险因素，特别是抗丙型肝炎病毒抗体（HCV）血清阳性。1992年6月，对3，575名30岁以上的居民进行了基线调查，包括HCV血清阳性、其他血清学试验和几种生活方式（1，150名男性和2，425名女性），据报道，1987年男性和女性的HCC年龄调整发病率分别高达47.2/10^5和10.2/10^5。方法：对1997年4 ~ 6月的随访资料进行回顾性分析，用考克斯比例风险模型估计各种原因死亡和新发肝癌的危险因素的危险比及其95%可信区间。结果：随访期间，各种原因死亡的男性73例，女性51例，死亡的男性12例，女性10例。 ...更多信息 随着年龄（趋势HR= 2.76，2.28 ~ 3.35）和性别（男性HR= 2.18，1.52 ~ 3.13）的增加，肝癌患者的死亡风险显著增加。对于男性，年龄调整后的死亡风险随着HCC的发生而显著增加（HR= 13.37，6.83 ~ 26.17），任何其他癌症（HR= 5.80，3.56 ~ 9.46），肝硬化（HR= 8.07，4.23 ~ 15.37），HCV血清阳性（HR= 2.38，1.42 -3.99）等。年龄调整后的死亡率风险随着患有除HCC以外的任何癌症而显著增加（HR= 18.11，10.40 ~ 31.53）、肝硬化（HR= 5.31，2.11 ~ 13.39）、肝病家族史（HR= 2.72，1.36 ~ 5.47）等。对于男性，HCV血清阳性者，年龄调整后患HCC的风险显著增加（HR= 74.56，9.60 ~ 579.32），戒酒（HR= 4.82，1.27 ~ 18.24），家族性肝病史（HR= 3.83，1.03 ~ 14.23），女性HCV阳性者患肝癌的年龄校正危险性显著增加（HR= 29.09，5.60 ~ 151.09）、戒酒（HR=24.22.3.06-191.66）等。少

项目成果

Mori,M.et al.: "Factors associated with hepatitis C virus transmission in the area of high incidence of hepatic cancer in Japan." Hepatology Research. 10・1. 17-26 (1998)

Mori, M.等：“日本肝癌高发地区丙型肝炎病毒传播的相关因素”10・1（1998）。

Mori, M.et al.: "Factors associated with hepatitis C virus transmission in the area of high incidence of hepatic cancer in Japan." Hepatology Research. 10・1. 17-26 (1998)

Mori, M.等人：“日本肝癌高发地区丙型肝炎病毒传播的相关因素”10・1（1998）。

Mori, M., Inutsuka, H., Wada, I., Yamamoto, K., Honda, M., and Naramoto, J: "Factors associated with hepatitis C virus transmission in the area of high incidence of hepatic cancer in Japan" Hepatology Research. 10(1). 17-26 (1998)

Mori, M.、Inutsuka, H.、Wada, I.、Yamamoto, K.、Honda, M. 和 Naramoto, J：“日本肝癌高发地区丙型肝炎病毒传播的相关因素”