The study on risk factors for prostate cancer according to production of equol, a metabolite of isoflavone.

根据异黄酮代谢物雌马酚的产生来研究前列腺癌的危险因素。

• 批准号: 19390176
• 负责人: MORI Mitsuru
• 金额: $ 8.74万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390176/
• 关键词: 前立腺がん; 症例対照研究; イソフラボン; エコール; 前立腺がんの家族歴; 乳がんの家族歴; 体重増加; 交互作用; リスク要因; エクオール; ダイゼイン; ゲニステイン; グリシテイン

For equol producers with prostate cancer (PCa), family history of PCa, family history of breast cancer and weight gain≧10kg from 20 years old were significantly associated with elevated risk of PCa. Contrastly, for equol non-producer with PCa, family history of PCa was significantly associated with increased risk of PCa, but family history of breast cancer as well as weight gain≧10kg from 20 years old were not associated with risk of PCa. Accordingly, it has been suggested that a risk factor for PCa may be different between equol producer and equol non-producers.

对于前列腺癌（PCa）患者，PCa家族史、乳腺癌家族史及20岁后体重增加≧10kg与PCa风险升高显著相关。相比之下，对于雌马酚不产生者，PCa家族史与PCa风险增加显著相关，但乳腺癌家族史和20岁以上体重增加≧10kg与PCa风险无相关性。因此，有研究表明，雌马酚产生者和非雌马酚产生者患前列腺癌的危险因素可能不同。

项目成果

A case-control study on risk factors for prostate cancer : Results of Analysis stratified by equol producer or non-producer

前列腺癌危险因素的病例对照研究：按雌马酚生产者或非生产者分层的分析结果

• 发表时间: 2010
• 作者: Mori M;et al.
• 通讯作者: et al.

A case-control study on risk factors for prostate cancer: Results of analysis stratified by equol producers or non-producers

前列腺癌危险因素的病例对照研究：按雌马酚生产者或非生产者分层的分析结果

• 发表时间: 2010
• 作者: Anazawa;Y.;et al.;大日方大亮;平尾佳彦;Mori M
• 通讯作者: Mori M

The interaction of genes and isoflavones intake on prostate cancer risk

基因和异黄酮摄入量对前列腺癌风险的相互作用

• 发表时间: 2007
• 作者: Akaza;H;el al.;Sonoda T
• 通讯作者: Sonoda T

無作為抽出した住民を対照群とした前立腺がんの症例対照研究によるリスク要因の検索.

通过使用随机选择的居民作为对照组的前列腺癌病例对照研究来寻找危险因素。

• 发表时间: 2009
• 作者: 森満;舛森直哉;福多史昌;宮永直人;赤座英之;塚本泰司
• 通讯作者: 塚本泰司

前立腺がん患者における血中イソフラボン類濃度間の相関と大豆製品摂取頻度との関連

前列腺癌患者血液异黄酮浓度与豆制品摄入频率的相关性

• 发表时间: 2009
• 作者: Anazawa;Y.;et al.;大日方大亮;平尾佳彦;Mori M;Mori M;塩田真己;Ide H;Ide H;Takahashi S;Yamaguchi K;Ide H;塩田真己;森満
• 通讯作者: 森満