A Study on the Effectiveness of Mass Screening for Cancer Using the Prefectural Cancer Registry

利用都道府县癌症登记处进行癌症大规模筛查的有效性研究

• 批准号: 10670355
• 负责人: MORI Mitsuru
• 金额: $ 1.22万
• 依托单位: Sapporo Medical University School of Medicine (1999)佐賀医科大学 (1998)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670355/
• 关键词: Mass screening; Survival analysis; Gastric neoplasms; Cervical neoplasms; Lung neoplasms; Intestinal neoplasms; Breast neoplasms; コホート研究; 症例対照研究

Purpose: We conducted a survival analysis to assess the effectiveness of mass screening program for gastric, cervical, lung, intestinal, and breast cancers in Saga Prefectural using the data from the Saga Prefectural Cancer Registry.Methods: We utilized the data of the Saga Prefectural Cancer Registry from January, 1982 to December, 1996. We defined the screened group as patients whose cancer was first detected by the screening program, and assigned residual patients to the non-screened group. The number of cancer case in the screened and the non-screened group, were as follows, respectively: 1,451 and 8,325 of gastric cancer, 188 and 817 of cervical cancer, 544 and 3,778 of lung cancer, 210 and 4,537 of intestinal cancer, and 85 and 1,847 cases of breast cancer. We compared the 14-years cumulative survival rates of the screened group to those of the non-screened group by cancer site. Hazard ratios and their 95% confidence intervals for mortality regarding screening program were estimated with the Cox' proportional hazard model.Results: The screened group showed the significantly higher 14-years cumulative survival rates than the non-screened group regarding each screening program for gastric, cervical, lung, intestinal, and breast cancer. The risk in mortality was significantly decreased when cancer was detected by the screening program. The age and sex-adjusted hazard ratios (and their 95 % confidence intervals) for mortality of the screening program were 0.40 (0.36-0.44) for gastric cancer, 0.41 (0.27-0.62) for cervical cancer, 0.51 (0.45-0.57) for lung cancer, 0.45 (0.32-0.62) for intestinal cancer, and 0.43 (0.20-0.90) for breast cancer.Conclusion: Mass screening program for gastric, cervical, lung, intestinal, and breast cancer is thought to be effective in terms of 14-years cumulative survival rates according to the Saga Prefectural Cancer Registry.

目的：我们进行了生存分析，以评估胃癌，宫颈癌，肺癌，肠癌和乳腺癌在佐贺县使用的数据从佐贺县癌症Registry.Methods的大规模筛查计划的有效性：我们利用的数据从1982年1月至1996年12月的佐贺县癌症登记。我们将筛查组定义为通过筛查程序首次检测到癌症的患者，并将剩余患者分配到未筛查组。筛查组和未筛查组的癌症病例数分别为：胃癌1 451例和8 325例，宫颈癌188例和817例，肺癌544例和3 778例，肠癌210例和4 537例，乳腺癌85例和1 847例。我们通过癌症部位比较了筛查组与非筛查组的14年累积生存率。采用考克斯' proportional hazard model.Results：筛查组胃癌、宫颈癌、肺癌、肠癌、乳腺癌的14年累积生存率均显著高于非筛查组。当筛查项目检测到癌症时，死亡风险显著降低。年龄和性别调整的风险比筛查项目的死亡率（及其95%置信区间）为0.40（0.36-0.44）胃癌，0.41（0.27-0.62）宫颈癌，0.51（0.45-0.57）肺癌，0.45（0.32-0.62），0.43（0.20-0.90）。结论：根据佐贺县癌症登记处的数据，胃癌、宫颈癌、肺癌、肠癌和乳腺癌的大规模筛查计划被认为在14年累积生存率方面是有效的。