A CASE-CONTROL STUDY OF OVARIAN CANCER.SURVEY IN JAPAN FOR COMPARISON AMONG JAPANESE IN JAPAN,JAPANESE IN U.S.A., AND WHITE IN U.S.A.

日本卵巢癌调查的病例对照研究，以比较在日本的日本人、在美国的日本人和在美国的白人

• 批准号: 06670425
• 负责人: MORI Mitsuru
• 金额: $ 0.7万
• 依托单位: Saga Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670425/
• 关键词: Ovarian cancer; Case-control studies; Family history; Body weight; Body mass index; Reproductive history; Oral contraceptives; Infertility; 卵巣がん; リスク要因

Purpose : To analyze the association between the potential risk factors and ovarian cancer among Japanese women.Method : We conducted a case-control study from October, 1994 to January, 1996, in northern Kyushu. We interviewed 78 cases whose ovarian cancer was histologically confirmed, and 346 controls who were identified at mass screening and who were evaluated as not having a cancer or an ovarian disorder. An odds ratio (OR) and its 95% confidence interval (95%CI) was estimated with the conditional logistic regression.Results : The risk was significantly increased for family history of ovarian cancer in a mother or a sister (OR=2.85,95%CI 1.01-8.08), for heavier maximum body weight in the past (trend, OR=1.35,95%CI 1.06-1.63), and for larger maximum body mass index (trend, OR=1.30,95%CI 1.06-1.60). Conversely, the risk was significantly decreased with the number of pregnancy (trend, OR=0.67,95%CI 0.51-0.89), with the number of parity (trend, OR=0.57,95%CI 0.39-0.83), and with experience in having ever taken oral contraceptive pills (p<0.05, OR could not be calculated because of null frequency in the cases).Treatment with hormonal drugs for infertility or menstrual disorder was not associated with the ovarian cancer risk.Discussion : The positive relationship of maximum body weight or body mass index to the ovarian cancer risk may in part explain the recent increase of the incidence of ovarian cancer in Japan.

目的：分析潜在危险因素与日本女性卵巢癌的关系。方法：1994年10月~ 1996年1月在九州北部进行病例对照研究。我们采访了78例经组织学证实的卵巢癌患者，以及346例在大规模筛查中被确定为没有癌症或卵巢疾病的对照组。用条件logistic回归估计比值比（OR）及其95%置信区间（95% ci）。结果：母亲或姐妹中有卵巢癌家族史（or =2.85,95%CI 1.01-8.08）、过去最大体重较大（or =1.35,95%CI 1.06-1.63）、最大体重指数较大（or =1.30,95%CI 1.06-1.60）者患卵巢癌的风险显著增加。相反，与怀孕次数（趋势值，OR=0.67,95%CI 0.51-0.89）、胎次（趋势值，OR=0.57,95%CI 0.39-0.83）和服用过口服避孕药的经历（p<0.05，由于病例为零频率，OR无法计算）相关的风险显著降低。用激素类药物治疗不孕症或月经紊乱与卵巢癌风险无关。讨论：最大体重或身体质量指数与卵巢癌风险的正相关关系可能部分解释了最近日本卵巢癌发病率增加的原因。