Life-style related risk factors for ovarian and endometrial cancer in a case-control study

病例对照研究中与生活方式相关的卵巢癌和子宫内膜癌危险因素

• 批准号: 16590505
• 负责人: MORI Mitsuru
• 金额: $ 2.18万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590505/
• 关键词: Ovarian cancer; Endometrial cancer; Case-control studies; Risk factors; Dietary factors; Physical activities; Reproductive history; Obesity; 生活習慣

Because it has been suggested that environmental factors may play a role in the etiology of ovarian cancer and, endometrial cancer, a hospital-based case-control study was conducted to assess some environmental and other risk factors associated with ovarian or endometrial cancer from 2003 to 2005 in Hokkaido Japan. Firstly, we analyzed the data of 71 cases with epithelial ovarian cancer from the Sapporo Medical University Hospital and 269 controls selected from the residential registries in areas same to those of the cases. After controlling for age and location, a significantly increased risk of ovarian cancer was observed to be associated with frequent consumption of rice (trend, P=0.0248), as well as beef and/or pork (trend, P=0.0259). A Significantly decreased risk was associated with higher frequency of physical activity (trend, P=0.00320). Trends in relation to a significant decrease in risk were obtained as number of pregnancies (trend, P=0.0371) and number of live births (trend … More , P=0.0180). This study provides additional findings on the association of suggested risk factors with risk of ovarian cancer in Japan.Secondly, we analyzed the data of 124 cases with endometrial cancer and 269 controls without any cancer. After controlling for the effect of potential confounders, frequent consumption of fried soybean curd (P=0.033), cabbage (P=0.018), other white vegetables (P=0.037), and alcohol drinking habits (P=0.033) was significantly associated with the decreased risk of endometrial cancer. Significantly decreased risks were noted for frequencies or duration of physical activities (P<0.05). Body weight and body mass index (BMI, P<0.01), heaviest non-pregnant body weight and BMI at the time of heaviest body weight (P<0.01), and maximum weight gain since 20 years (P<0.001) were all associated with the increased risk of endometrial cancer. Significantly decreased trends for risk were obtained for the number of pregnancies (P<0.01) and the number of livebirths (P<0.001). The experience in taking oral contraceptives was significantly associated with the reduced risk of endometrial cancer (P=0.038). A history of endometrial cancer in a mother or sister was significantly associated with the increased risk of endometrial cancer (P=0.041). An avoidance of obesity through increase in physical activities may be a practical means for primary prevention of endometrial cancer. Less

由于环境因素可能在卵巢癌和子宫内膜癌的病因中起作用，2003年至2005年在日本北海道进行了一项以医院为基础的病例对照研究，以评估与卵巢癌或子宫内膜癌相关的一些环境因素和其他危险因素。首先对札幌市医科大学附属医院收治的71例上皮性卵巢癌患者的资料进行了分析，并从与病例相同的地区的居民登记处选择了269例对照。在控制了年龄和地理位置后，卵巢癌的风险显著增加与经常食用大米(趋势，P=0.0248)以及牛肉和/或猪肉(趋势，P=0.0259)有关。风险显著降低与较高的体力活动频率相关(趋势，P=0.00320)。与显著降低风险相关的趋势是怀孕数量(趋势，P=0.0371)和活产数量(趋势…更多，P=0.0180)。第二，我们分析了124例子宫内膜癌患者和269例对照组的资料。在控制潜在混杂因素的影响后，经常食用油炸豆腐(P=0.033)、卷心菜(P=0.018)、其他白色蔬菜(P=0.037)和饮酒习惯(P=0.033)与子宫内膜癌的风险降低显著相关。体力活动的频率或持续时间的风险显著降低(P&lt；0.05)。体重和体重指数(P&lt；0.01)、未怀孕时的最重体重和体重最重时的体重指数(P&lt；0.01)以及20年来的最大体重增长(P&lt；0.001)都与子宫内膜癌的风险增加有关。妊娠数(P&lt；0.01)和活产数(P&lt；0.001)的风险有显著下降的趋势。服用口服避孕药的经历与降低子宫内膜癌的风险显著相关(P=0.038)。母亲或姐妹的子宫内膜癌病史与子宫内膜癌风险的增加显著相关(P=0.041)。通过增加体力活动来避免肥胖可能是子宫内膜癌一级预防的一种实用方法。较少

项目成果

I.女性性器癌-概論-癌の予防

一、女性生殖器癌症-概述-癌症预防

• 发表时间: 2004
• 期刊: 日本臨床 62巻増刊号10
• 作者: 森 満;寒河江 悟
• 通讯作者: 寒河江 悟

The reproducibility of a binary tumor grading system for uterine endometrial endometrioid carcinoma, compared with FIGO system and nuclear grading

• DOI: 10.1159/000082917
• 发表时间: 2004-01-01
• 期刊: ONCOLOGY
• 影响因子: 3.5
• 作者: Sagae, S;Saito, T;Kudo, R
• 通讯作者: Kudo, R

I.女性性器癌-概論- 癌の予防

I. 女性生殖器癌症 - 概述 - 癌症预防

• 发表时间: 2004
• 期刊: 日本臨床 62巻増刊号10
• 作者: 森 満;寒河江 悟
• 通讯作者: 寒河江 悟

Dietary habits and risk of ovarian cancer death in a large-scale cohort study (JACC study) in Japan

• DOI: 10.1080/01635580701274178
• 发表时间: 2007-01-01
• 期刊: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
• 影响因子: 2.9
• 作者: Sakauchi, Fumio;Khan, M. M. H.;Tamakoshi, Akiko
• 通讯作者: Tamakoshi, Akiko

Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan.

• 发表时间: 2006
• 期刊: Asian Pacific journal of cancer prevention : APJCP
• 作者: Mmh Khan;M. Mori;F. Sakauchi;Khandoker Aklimunnessa;T. Kubo;Y. Fujino;Sadao Suzuki;S. Tokudome;Akiko Tamakosh