RESEARCH ON NEUROTOXICITY OF NMDA ANTAGONIST AND THE EFFECTS OF ANESTHETICS ON THE NEUROTOXICITY

氯胺酮是一种非竞争性NMDA拮抗剂，具有拟精神病活性（不良心理反应）。最近的研究表明，NMDA拮抗剂引起扣带皮层的形态学损害，这被认为是负责其精神病样活动的脑区。在本研究中，我们已经证明，氯胺酮诱导显着的c-Fos蛋白（c-Fos）的表达，这被认为是一个很好的代谢指标，在大鼠扣带皮层。我们还证明，地西泮，氟烷，丙泊酚在临床剂量抑制诱导剂量依赖性的方式。这些结果提供了神经元的基础，这些药物防止氯胺酮诱导的拟精神病活动。

Ketamine, a noncompetitive NMDA antagonist, has psychotomimetic activity (undesirable psychological reactions). Recent studies have shown that NMDA antagonists cause morphological damages in the cingulate cortex, which is suggested to be the responsible brain region for their psychotomimetic activity. In the present research, we have demonstrated that ketamine induced marked c-fos protein (c-Fos) expression, which is suggested to be a good metabolic marker, in the rat cingulate cortex. We also demonstrated that diazepam, halothane, and propofol at clinical doses inhibited the induction in a dose-dependent manner. These results provide the neuronal basis that these drugs prevent ketamine-induced psychotomimetic activity.