Role of heat shock proteins in oral mucosal diseases and focal in fection

热休克蛋白（HSP）是由多种应激诱导的高度保守的免疫原性分子。微生物和人类热休克蛋白之间的结构同源性被认为是慢性炎症性疾病自身免疫的基础。采用ELISA法测定掌足底脓疱病（PPP）患者血清GloEL/GroES、牛分枝杆菌BCG HSP65和重组人HSP60抗体水平。与健康对照组相比（n=22,0.218(]SY.+- - [)0.176）， PPP患者血清抗GroEL/GroES lgG抗体升高（n=43, 0.342(]SY.+- [)0.246, p<0.05），但抗牛m.s HSP65和r-human HSP60抗体差异无统计学意义。抗GroEL/GroES抗体水平与r-human HSP60呈正相关。PPP作为一种局灶性传染病，细菌热休克蛋白60可能是抗原，但人热休克蛋白60不是自身抗体。

Heat shock proteins (HSP) are highly conserved immunogenic molecules that are induced by a variety of stresses. Structural homology between microbial and human HSP has been postulated to be a basis for autoimmunization in chronic inflammatory diseases. We estimated by ELISA titration the antibody levels to GloEL/GroES,Mycobacterium bovis BCG HSP65 and recombinant human HSP60 in sera of patients with palmoplantar pustulosis (PPP). In comparison with healthy controls (n=22,0.218(]SY.+-。[)0.176), serum anti GroEL/GroES lgG antibodies were elevated in PPP (n=43, 0.342(]SY.+-。[)0.246, p<0.05), but anti M.bovis HSP65 and r-human HSP60 antibodies were not significant difference. There were a correlation between levels of anti GroEL/GroES antibody and r-human HSP60. In PPP, as a focal infectious disease, bacterial HSP might be a antigen, but human HSP60 not be autoantibody.