Gold standard methods for fluoride analysis

氟化物分析的金标准方法

• 批准号: 6619543
• 负责人: ESPERANZA A MARTINEZ-MIER
• 金额: $ 15.05万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6619543
• 关键词: animal tissue; dental caries; dental caries inhibitor; disease /disorder prevention /control; fluorine; human tissue; measurement; method development; oral health; preventive dentistry; sample collection; technology /technique development

DESCRIPTION (provided by applicant): Fluoride is widely recognized for reducing the prevalence of Dental caries. Therefore, either studies aimed to enhance its beneficial effects or to reduce its detrimental effects continues to be relevant. Such studies can benefit from improvements in the techniques employed for the analysis of fluoride. In addition, meaningful international studies in this field can only be conducted if standardized methods for measuring the levels, ingestion and concentrations of fluoride, are available. Currently available fluoride measurement techniques are not standardized and a universal standard for fluoride determination has not been established. Although a variety of techniques are available, none have been accepted for universal use. The current project Aims to collaborate with established analytical laboratories to develop standard, global methods for analyzing fluoride in different types of samples. In order to develop these standard, global methods for fluoride analysis, the Fluoride Laboratory at the Oral Health Research Institute proposes to collaborate with six, additional, well-established laboratories that are currently conducting fluoride analyses. The proposed collaboration will include the analysis of the fluoride content of a series of 180 biological and environmental samples using the methods in current use in each laboratory. Results of these analyses and descriptions of the analytical procedures used will be collected and distributed from each laboratory to all collaborators. A plan will be then developed to resolve any differences in results and to identify preferred analytical procedures in a meeting of all collaborators at the Oral Health Research Institute. Analyses of another series of biological samples by all laboratories using the preferred analytical methods will be then conducted and, finally a scientific paper reviewing the data collected and the preferable analytical procedures will be developed for publication. The proposed investigation will provide an opportunity for seven recognized laboratories to collaborate in order to reach consensus about detailed protocols that will identify and describe gold standard techniques for fluoride analysis of specific types of samples. The proposed study will provide an opportunity to resolve discrepancies that currently make it difficult to compare the results of the many studies dealing with fluoride analyses.

描述（由申请人提供）：氟化物被广泛认为可以减少龋齿的发病率。因此，旨在增强其有益影响或减少其有害影响的研究仍然是相关的。这类研究可得益于氟化物分析技术的改进。此外，只有具备测量氟化物水平、摄入和浓度的标准化方法，才能在这一领域进行有意义的国际研究。目前可用的氟化物测量技术没有标准化，也没有建立一个测定氟化物的通用标准。虽然有各种各样的技术可供使用，但没有一种被普遍接受。目前的项目旨在与已建立的分析实验室合作，制定分析不同类型样品中氟化物的标准全球方法。

项目成果

[Evaluation of the fluorine content in fluoridated table salt].

[氟化食盐中氟含量的评价]。

• DOI: 10.1590/s0036-36342004000300004
• 发表时间: 2004
• 期刊: Salud publica de Mexico
• 影响因子: 2.3
• 作者: MartínezMier,EAngeles;SotoRojas,ArmandoE;Buckley,ChristineM;Stookey,GeorgeK;Zero,DomenickT;Margineda,Jorge
• 通讯作者: Margineda,Jorge

Evaluation of the direct and diffusion methods for the determination of fluoride content in table salt

• DOI: 10.1922/cdh_2306martinez-mier07
• 发表时间: 2009-12-01
• 期刊: COMMUNITY DENTAL HEALTH
• 影响因子: 1.7
• 作者: Martinez-Mier, E. A.;Soto-Rojas, A. E.;Zero, D. T.
• 通讯作者: Zero, D. T.