Basic Research for AIDS control A02 ; Pathophysiology and immunology of HIV-1 infection
Basic Research for AIDS control A02 ; Pathophysiology and immunology of HIV-1 infection
批准号:
10180102
负责人:
UCHIYAMA Takashi
金额:
$144.7万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas (A)
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 2001
中文摘要
我们主要对HIV-1感染中的趋化因子/趋化因子受体系统和HIV-1特异性CTL进行了研究,取得了许多成果,如下所述。Uchiyama报道说,天然的α干扰素产生细胞是某些树突状细胞亚群的前体,在先天免疫反应中发挥关键作用,它可以感染HIV-1,并在感染HIV-1时产生大量的α干扰素,以分化为树突状细胞。长泽鉴定了最不成熟的前体B细胞的一个子集,并表明SDF-1对于使用各种基因敲除小鼠发展这个细胞亚群是必不可少的。Yoshie分析了淋巴器官中结构性表达的免疫趋化因子在HIV-1感染中的作用。他还分析了P2G-SDF-1-Fc嵌合蛋白对HIV-1感染的抑制作用。Kiyono报道,gp160融合脂质体经鼻粘膜免疫不仅在野生型小鼠中诱导了中和抗体应答,而且在干扰素-γ基因敲除小鼠或IL-4基因敲除小鼠中也诱导了中和抗体应答,提示该疫苗可能作为治疗性疫苗。Takahashi报道了CTL对HIV-1感染的详细反应机制。Takizawa发现,HIV-1特异性CD8()CTL在其表面表达CCR5,并被该配体迁移,表明这些趋化因子可能参与了Th1反应的诱导。
英文摘要
We have been worked mainly on chemokine/chemokine receptor system in HIV-1 infection and HIV-1-specific CTL, and got many results as described below. Uchiyama reported that natural alpha interferon-producing cells, which was a precursor of certain dendritic cell subsets and played a crucial role in an innate immune response, could be infected with HIV-1 and produce a large amount of alpha interferon in response to HIV-1 infection to differentiate into dendritic cells. Nagasawa identified a subset of the most immature precursor B cells and showed that SDF-1 is essential for the development of this cell subset using various knockout mice. Yoshie analyzed the role of immune chemokine constitutively expressed in lymphoid organs in HIV-1 infection. He also analyzed the suppressive effect of P2G-SDF-1-Fc chimeric protein on HIV-1 infection. Kiyono reported that immunization with gp160-fusogenic liposome through nasal mucosa induced the neutralizing antibodies response in not only wild type mice but also IFN-γ-knockout mice or IL-4-knockout mice, indicating a possible implication of this vaccine as a therapeutic vaccine. Takahashi reported detailed mechanism of CTL response to HIV-1 infection. Takizawa found that HIV-1-specific CD8(+) CTL expressed CCR5 on their surfaces and migrated by this ligand, indicating that these chemikines might be involved in the induction of Th1 response.
期刊论文(8)
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Suzuki Y: "Determinant in human immunodeficiency virus type 1 for efficient replication in cytokine induced CD4+ T helper 1 (Th1)- and Th2-type conditions." J Virol. 73. 316-324 (1999)
Suzuki Y:“1 型人类免疫缺陷病毒在细胞因子诱导的 CD4 T 辅助细胞 1 (Th1) 和 Th2 型条件下有效复制的决定因素。”
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Hiroi, T: "HIV mucosal vaccine : nasal immunization with rBCG-V3J1 induces a long-term V3J1-peptide-specific neutralizing immunity in Th1 and Th2 deficient conditions"J. Immunol.. 167. 5862-5867 (2001)
Hiroi, T:“HIV 粘膜疫苗:rBCG-V3J1 鼻腔免疫可在 Th1 和 Th2 缺陷条件下诱导长期 V3J1 肽特异性中和免疫”J.
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Zlotnik,A: "Chemokines : a new classification system and their role in immunity."Immunity. 12. 121-127 (2000)
Zlotnik,A:“趋化因子:一种新的分类系统及其在免疫中的作用。”免疫。
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Suzuki, Y.: "Determinant in human immunodeficiency virus type 1 for efficient replication under cytokine induced CD4+ T helper 1 (Th1)- and Th2-type conditions"J Virol. 73. 316-324 (1999)
Suzuki, Y.:“1 型人类免疫缺陷病毒在细胞因子诱导的 CD4 T 辅助细胞 1 (Th1) 和 Th2 型条件下有效复制的决定因素”J Virol。
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Sakaida H.: "T-tropic human immunodeficiency virus type 1 (HIV-1)-derived V3 loop peptides directly bind to CXCR-4 and inhibit T-tropic HIV-1 infection." J Virol. 72 (2). 9763-9770 (1998)
Sakaida H.:“T 向性人类免疫缺陷病毒 1 型 (HIV-1) 衍生的 V3 环肽直接与 CXCR-4 结合并抑制 T 向性 HIV-1 感染。”
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国内基金
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