Study on ability of Maxillo-facial growth in the patients with congenital anomalies by HLA-typing

HLA分型研究先天性畸形患者颌面部生长能力

• 批准号: 10557195
• 负责人: SUSAMI Takafumi
• 金额: $ 6.27万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10557195/
• 关键词: CL (Cleft Lip); CLP (Cleft Lip and Palate); HLA-B; HLA-DRB1; Japanese; HLA-DRBI; 口唇・口蓋裂; HLA; 遺伝子多型解析

Nucleotide sequence level typing of HLA-B, -DRB1, and -DPB1 alleles was performed on Japanese patients with cleft lip with or without cleft palate (CL/P). Two HLA-B alleles, B*1501 and B*5101, showed a significant positive association with CL/P. The increase of B*1501 was evident in female patients (OR = 3.6, pc = 0.005), whereas the increase of B*5101 was evident in male patients (OR = 3.7, pc < 0.002). One HLA-DRB1 allele, HLA-DRB1*0802 also showed an increase in CL/P patients. Conversely, HLA-B*4403 End DRBl*1302 were not observed in the patient group (pc = 0.004 and pc = 0.007, respectively). No HLA-DPB1 alleles showed significant association with CL/P. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of CL/P.

对日本唇裂伴或不伴腭裂（CL/P）患者进行HLA-B、-DRB 1和-DPB 1等位基因的核苷酸序列水平分型。两个HLA-B等位基因B*1501和B*5101与CL/P呈显著正相关，女性患者中B*1501的增加明显（OR = 3.6，pc = 0.005），而男性患者中B*5101的增加明显（OR = 3.7，pc < 0.002）。一个HLA-DRB 1等位基因，HLA-DRB 1 *0802也显示CL/P患者的增加。相反，在患者组中未观察到HLA-B*4403和DRB 1 *1302（分别为pc = 0.004和pc = 0.007）。没有HLA-DPB 1等位基因显示与CL/P有显著关联。因此，本研究表明，HLA等位基因或紧密连锁的基因座可能参与CL/P的发病机制。

项目成果

Y. Sakata, et al.: "Significant association of HLA-B and HLA-DRB1 alleles with cleft lip with or without cleft palate"Tissue Antigens. 53. 147-152 (1999)

Y. Sakata 等人：“HLA-B 和 HLA-DRB1 等位基因与有或没有腭裂的唇裂显着相关”组织抗原。

Y. Sakata, K. Tokunaga et al.: "Significant association of HLA-B and HIA-DRB1 alleles with cleft lip with or without cleft palate"Tissue Antigens. 53. 147-152 (1999)

Y. Sakata、K. Tokunaga 等人：“HLA-B 和 HIA-DRB1 等位基因与有或没有腭裂的唇裂显着相关”组织抗原。

坂田康彰、高戸 毅: "口唇口蓋裂の疫学的研究(13章 HLAによる解析)"東山書房. 204 (1998)

Yasuaki Sakata、Tsuyoshi Takato：“唇裂和腭裂的流行病学研究（第 13 章 HLA 分析）”东山书房 204（1998）。

Y.Sakata,et al.: "Significant association of HLA-B and HLA-DRB1 alleles with cleft lip with or without cleft palate"Tissue Antigens. 53. 147-152 (1999)

Y.Sakata 等人：“HLA-B 和 HLA-DRB1 等位基因与唇裂（伴或不伴腭裂）的显着关联”组织抗原。

Y.SAKATA: "Significant association of HLA-B and HLA-DRB1 alleles with CL/P" Tissue Antigens. 53(2). 147-152 (1999)

Y.SAKATA：“HLA-B 和 HLA-DRB1 等位基因与 CL/P 显着相关”组织抗原。