Novel bone tissue engineering method using PTH signaling, its application to secondary alveolar bone grafting in patients with CLP and orthodontic evaluation

本研究的目的是：(1)利用甲状旁腺激素(PTH)构建组织工程骨；(2)阐明PTH在骨形成中的作用机制；(3)从正畸角度评价该方法构建的组织工程骨作为植骨材料的质量。结果发现，甲状旁腺激素在体内和体外均能促进骨形成和骨分化。提示应用甲状旁腺激素或抑制G-α-Q信号通路可有效构建组织工程化骨，可应用于二期牙槽骨移植。

This study was conducted to (1) make tissue-engineered bone by using parathyroid hormone (PTH), (2) elucidate the mechanism of PTH function in bone formation and (3) evaluate the quality as a material for bone grafting of the tissue-engineered bone constructed by this novel method in terms of orthodontics. As a result, PTH was found to be able to promote bone formation and bone differentiation both in vivo and in vitro. It was suggested that use of PTH or suppression of Gαq signaling may be effective to produce tissue-engineered bone which could be applied to secondary alveolar bone grafting.