Molecular and Cellular biglogical study on the maxillotacial bone formation by orthognathic torce.

正颌扭矩作用下颌骨成骨的分子和细胞大逻辑研究。

• 批准号: 12671987
• 负责人: SUSAMI Takafumi
• 金额: $ 1.98万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671987/
• 关键词: Pistraction osteogenesis; rat; radiodense; molecular and cellular biology; 下顎骨; 骨延長; 顎矯正力; 組織学; 生化学

Distraction osteogenesis is a powerful technique capable of generating viable osseous tissue by the gradual separation of osteotomized bone edges. Although the histologic and radiologic changes associated with this process have extensively delineated, the molecular events governing these changes remain essentially unknown. We have devised a rat model of mandibular distraction osteogenesis that facilitates molecular analysis of this process. Such information has significant clinical implications because it may enable targeted therapeutic manipulations designed to accelerate osseous regeneration. We have evaluated the macroscopic observations and radiographic changes in this study, and the bone in the distraction areas of the 4-week subgroups was radiodense, equivalent to the original bone. We examine the molecular and cellular biological study now.

牵张成骨是一种强大的技术，能够通过逐渐分离截骨骨边缘来产生有活力的骨组织。虽然与此过程相关的组织学和放射学变化已被广泛描述，但控制这些变化的分子事件基本上仍不清楚。我们设计了一种大鼠下颌骨牵张成骨模型，有助于对这一过程进行分子分析。这些信息具有重要的临床意义，因为它可能使有针对性的治疗操作，旨在加速骨再生。我们评估了本研究中的肉眼观察结果和影像学变化，4周亚组的牵引区骨具有放射致密性，与原始骨相当。我们现在检查分子和细胞生物学研究。