Molecular biology research concernig mandible face growth of Hemifacial Microsomia

半面部微小症下颌面部生长的分子生物学研究

• 批准号: 09672093
• 负责人: SUSAMI Takafumi
• 金额: $ 2.3万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672093/
• 关键词: Endothelin-1; Meckel cartilage; mesenchymal cell; pharyngeal arch; mandibular process; maxillar process; エンドセリン-1; 神経堤細胞; 上皮間葉相互作用; 第一鰓弓

Endothelin-1 (ET-1) isa potent vasoconstrictor that was first purified from cultured porcine endothelial cells. Recently, gene targeting of ET-1 reveals its role in the formation of craniofacial structures including bones and cartilage.When the phenotype of ET-1 gene deletion mouse's homozygote (ET-1 (-l-)) and heterozygote and wild type (ET-1 (+/+, +/-))was compared and had been examined, the sinus hair of a lower jaw all opatry which presented the faulty union of the median of all sample lower jaw, making to the maxilla, and hypoplasia of the pinna in the homozygote and was similar to the maxillary sinus hair in addition was admitted.Bone and cartilage specimen : the mandibular process articularise quivalent part were similarto the arcus zygomaticus projection on complete deletion, the malleus, and the anulus tympanicus complete Loss, like in the axis Meckel cartilage.Running of blood vessel : In ET-1 (-l-), an abnormal offshoot lingua arteria labialis inferior excessive branch exist … More ed from the arteria facialis in the plural and the form was similar to the arteria maxillaris of the upper jaw.Tissue image : It was not admitted in ET-1 (-l-) though the increase of the substrate between cells was admitted for the viviparity 10.5 days by the mesenchymal cell right under the head side pharyngeal arch cuticle of ET-1 (+l*).Appearance of gene : HANDs was compared in the PAX3 domination and the mandibular process in the maxillar process though it was dominant and PAX3 was dominant in both maxillar process and mandibular processes in ET-1 (-l-).Abnormality of ET-1 (-l-)concentrated on the structure of the mandibular process origin and originality in the form of the lower jaw was thought to give ET-1 from the admission of two or more upper jaw externals pathomorphisms of the lower jaw and the pattern of manifestation of the gene in the ET-1 (-l-) mandibular process similar the processus maxillaris and well by acting on a mesenchymal cell the germinal layer and adjusting the appearance of dHAND, eHAND, and Pax3 to the migration from neural crest cell. Less

内皮素-1(ET-1)是一种最早从培养的猪内皮细胞中提纯的强效血管收缩因子。近年来，ET-1基因打靶研究揭示了其在骨骼、软骨等颅面结构形成中的作用。对ET-1基因缺失小鼠纯合子(ET-1(-L-))和杂合子与野生型(ET-1(+/+，+/-))的表型进行比较和检测时，发现一例下颌窦毛发全开放，表现为所有标本的下颌正中线畸形结合，致上颌骨。骨和软骨标本：下颌突关节等价部类似颧弓投影完全缺失，锤、鼓环完全消失，类似于Meckel软骨轴线。血管运行：在ET-1(-L-)中，存在异常的舌侧舌动脉下支过多的…更多来自复数形式的面动脉，其形状类似于上颌骨的上颌动脉。问题图：ET-1(-L-)的头侧咽弓角质层正下方的间充质细胞接受胎盘10.5天细胞间基质增加，但ET-1(-L-)不接纳它。基因的出现：比较了手在ET-1(+L*)的颌突和下颌突中的优势，但在ET-1中，PAX3在上颌突和下颌突中都占优势。L)。ET-1(-L-)的异常集中在下颌突的结构上，起源和起源于下颌骨的形式，被认为是由于两个或两个以上的上颌外部组织的进入而引起的下颌骨的病理形态和基因在ET-1(-L-)下颌突中的表现模式，通过作用于间充质细胞的生发层和调节DHAND的外观而良好。EHAND和Pax3对神经脊细胞的迁移有促进作用。较少