Endothelium-dependent and -independent responses of coronary arteriole to pulsatile mechanical stress in vivo

冠状动脉对体内脉动机械应力的内皮依赖性和非依赖性反应

• 批准号: 10670694
• 负责人: GOTO Masami
• 金额: $ 1.86万
• 依托单位: Kawasaki College of Allied Health Professions
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670694/
• 关键词: subendocardium; arteriole; mechanical stress; pulse pressure; myogenic regulation; vascular response; myocardial ischemia; microcirculation

We organized this project in order to provide a better understanding of the physiological importance of the endothelium-dependent and -independent regulations of coronary arteriole under pulsatile mechanical stress. Followings are the major findings this project.With aids of needle-probe CCD intravital microscopy and coronary perfusion system, we evaluated the behavior of the coronary arterioles in response to a reduction of coronary perfusion pressure. Pulsatile transmural pressure of the arterioles contributed to the arteriolar dilation in response to a decrease in coronary perfusion pressure. At the same time, diastolic time fraction increased when coronary flow was reduced by lowering perfusion pressure. These pulsation-related vasodilation and modulation of diastolic perfusion time can provide an important regulatory mechanism to match supply and demand of the myocardium at low perfusion pressure, especially in the subendocardium.

我们组织了这个项目，以提供一个更好的了解的生理重要性的血管内皮依赖性和非依赖性的调节冠状动脉脉动机械应力。本课题的主要研究结果如下：利用针探头CCD活体显微镜和冠状动脉灌注系统，评价了冠状动脉灌注压降低对冠状动脉行为的影响。小动脉的脉动性跨壁压有助于小动脉对冠状动脉灌注压降低的反应性扩张。同时，当通过降低灌注压减少冠状动脉血流时，舒张时间分数增加。这些与搏动相关的血管舒张和舒张灌注时间的调节可以提供重要的调节机制，以在低灌注压下匹配心肌的供应和需求，特别是在内膜下。

项目成果

Takeshi Matsumoto,Jun Ebata,Masami Goto, et al.: "Transmural microcirculatory blood flow distribution in the right and left ventricular free wa1ls of rabbits"Am J Physiol. 277. H183-191 (1999)

Takeshi Matsumoto、Jun Ebata、Masami Goto 等人：“兔子右心室和左心室游离壁的跨壁微循环血流分布”Am J Physiol。

Merkus D, Kajiya F, Vink H, Vergroesen I, Dankelman J, Goto M, Spaan JAE.: "Prolonged diastolic time fraction protects myocardial perfusion when coronary blood flow is reduced."Circulation. 100. 75-81 (1999)

Merkus D、Kajiya F、Vink H、Vergroesen I、Dankelman J、Goto M、Spaan JAE.：“当冠状动脉血流量减少时，延长舒张时间可保护心肌灌注。”循环。