Subdivision brain capacity measurement and the aging with 3.0 T magnetic resonance imaging

将健康成人按年龄和性别分为8组，获得t1加权磁共振图像，分析脑容量变化。用基于体素的形态测量法（VBM）观察到，50多岁的女性（59名女性中有51名处于更年期）海马的双侧灰质体积明显小于40多岁的女性（46名女性中只有3名处于更年期）。然而，50多岁的女性组与60多岁、60多岁与70多岁、40多岁与50多岁、50多岁与60多岁、60多岁与70多岁的男性组之间没有显著差异。我们的研究结果表明，更年期可能与海马体积减少有关。

T1-weighted magnetic resonance images of healthy adults divided into eight groups by age and gender were obtained to analyze brain volume change. Significantly smaller gray matter volume was observed in the hippocampus bilaterally in females aged in their fifties (fifty one of 59 females were at menopause) compared to females in their forties (the only three of 46 females were at menopause), with voxel-based morphometry (VBM). However, No significant difference were found between the female groups in fifties vs sixties, sixties vs seventies, or the male groups in forties vs fifties, fifties vs sixties, sixties vs seventies. The results of our study suggest that the menopause may be associated with hippocampal volume reduction.