胎生期及び新生児期の母仔環境が成長後の生体調節系に及ぼす影響に関する基礎研究

胎儿及新生儿期母婴环境对生长后生物调节系统影响的基础研究

• 批准号: 10670905
• 负责人: NOZAKI Takehiro
• 金额: $ 1.86万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670905/
• 关键词: prenatal crowding stress,; maternal deprivation,; spatial cognitive behavior,; aggressive behavior,; corticosterone,; testosterone,; serotonin receptor

1). Effect of prenatal crowding stress or maaternal deprivation on cognitive behaviors in miceAn experiment was carried out to study the effect of prenatal crowding stress (PCS) or maternal deprivation (MD) during infancy on performance in a modified T-maze, an animal model of cognitive functions. Mice pups were divided into two groups : 1) pups of mothers exposed to crowding stress from day 10 to 19 of pregnancy. 2) pups exposed daily to 1-hr deprivation from mothers and littermates from 5 to 22days of age. In PCS mice, success rates in trials were not declined at 7 weeks of age compared to control mice, but declined significantly at 20 weeks of age. the success rates were not declined at 7 and 20 weeks of ages in MD mice, compared with controls. Basal serum corticosteron tended to be increaed in PCS mice, whereas it was decreased in MD mice. The results indicate that PCS affects spatial cognitive behavior in adulthood. It might be related with the excess corticosterone secretion.2). … More Maternal deprivation-induced aggressive behavior in male miceA experiment was carried out study the effect of maternal deprivation in early life on the onset and development of aggressive behavior in male mice in later life. Aggression tests were done at 6, 12, 18 and 24 weeks of age. MD mice revealed higher aggression scores on and after 12 weeks of age. This suggests that aggressive behavior occurs in male mice on and after puberty. The pituitary and adrenal weights of MD mice were decreased and serum corticosterone levels were diminished at 6 and 20 weeks of age. These findings suggest that MD suppresses hypothalamus-pituitary-adrenal (HPA) response. Serum testosterone levels rose in MD male mice at 27 weeks of age. The numbers of 5-HTィイD21AィエD2 and 5-HTィイD22ィエD2 receptor binding sites in the whole brain were not significantly different between MD and non-MD mice at 6 and 42 weeks of age. In conclusion, the onset and development of aggressive behavior in MD male mice is associated with HPA function and testosterone. Further study is needed to evaluate the relationship between aggressiveness and the serotonin system in different brain areas. Less

1)产前拥挤应激或母亲剥夺对小鼠认知行为的影响本实验旨在研究婴儿期产前拥挤应激（PCS）或母亲剥夺（MD）对小鼠认知功能改良t迷宫模型表现的影响。将小鼠幼崽分为两组：1)在怀孕第10天至第19天暴露于拥挤压力下的母鼠幼崽。2) 5 ~ 22日龄的幼崽每天与母崽和幼崽隔离1小时。PCS小鼠的试验成功率在7周龄时与对照小鼠相比没有下降，但在20周龄时显著下降。与对照组相比，MD小鼠在7周龄和20周龄时的成功率没有下降。PCS小鼠的基础血清皮质酮水平有升高的趋势，而MD小鼠的基础血清皮质酮水平有下降的趋势。结果表明，PCS影响成人空间认知行为。可能与肾上腺皮质酮分泌过多有关。短句来源本实验旨在研究早期母性剥夺对成年雄性小鼠攻击行为发生和发展的影响。在6、12、18和24周龄时进行攻击测试。MD小鼠在12周龄时和12周龄后表现出更高的攻击得分。这表明攻击性行为发生在雄性小鼠的青春期前后。MD小鼠在6周龄和20周龄时垂体和肾上腺重量降低，血清皮质酮水平降低。这些发现表明MD抑制下丘脑-垂体-肾上腺（HPA）反应。27周龄时，MD雄性小鼠血清睾酮水平升高。在6周龄和42周龄时，MD小鼠与非MD小鼠全脑内5-HT小伙伴D21A小伙伴D2和5-HT小伙伴D22小伙伴D2受体结合位点的数量无显著差异。综上所述，MD雄性小鼠攻击行为的发生和发展与HPA功能和睾酮有关。攻击性与不同脑区血清素系统之间的关系有待进一步研究。少

项目成果

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Sudo N et al.: "Dietary nucleic promote a shift in Th1/Th2 balance toward Th-1-dominant immunity"Clin Exp Allergy. (accepted). (1999)

Sudo N 等人：“饮食核酸促进 Th1/Th2 平衡向 Th-1 主导免疫的转变”Clin Exp Allergy。

Nozaki T et al.: "Maternal deprivation induces aggressive behavior in male mice"Kor J Stress Res. 7. 41-46 (1999)

Nozaki T 等人：“母性剥夺会诱发雄性小鼠的攻击行为”Kor J Stress Res。