胎生期及び新生児期の母仔環境が成長後の生体調節系に及ぼす影響に関する基礎研究

1)。Effect of prenatal crowding stress or maaternal deprivation on cognitive behaviors in miceAn experiment was carried out to study the effect of prenatal crowding stress(PCS)or maternal deprivation(MD)during infancy on performance in a modified T-maze，an animal model of cognitive functions.Mice pups were divided into two groups：1)点数of mothers exposed to crowding stress from day 10 to 19 of pregnancy。2)pups exposed daily to 1-hr deprivation from mothers and littermates from 5 to 22 days of age。In PCS mice，success rates in trials were not declined at 7weeks of age compared to control mice，but declined significantly at 20 weeks of age。The success rates were not declined at7and20weeks of ages in MD mice，compared with controls。Basal serum corticosteron tended to be increaed in PCS mice，whereas it was decreased in MD mice.The results indicate that PCS affects spatial cognitive behavior in adulthood.It might be related with the excess corticosterone secretion.2)。……More Maternal deprivation-induced aggressive behavior in male miceA experiment was carried out study the effect of maternal deprivation in early life on the onset and development of aggressive behavior in male mice in later life.Aggression tests were done at 6，12，18 and 24 weeks of age。MD mice revealed higher aggression scores on and after12weeks of age。This suggests that aggressive behavior occurs in male mice on and after puberty.The pituitary and adrenal weights of MD mice were decreased and serum corticosterone levels were diminished at 6 and 20 weeks of age。These findings suggest that MD suppresses hypothalamus-pituitary-adrenal(HPA)response。Serum testosterone levels rose in MD male mice at 27 weeks of age.The numbers of 5-HT I D 21A I D 2 and 5-HT I D 22 I D 2 receptor binding sites in the whole brain were not significantly different between MD and non-MD mice at 6 and 42 weeks of age.In conclusion，the onset and development of aggressive behavior in MD male mice is associated with HPA function and testosterone。Further study is needed to evaluate the relationship between aggressiveness and the serotonin system in different brain areas.Less：Less

1). Effect of prenatal crowding stress or maaternal deprivation on cognitive behaviors in miceAn experiment was carried out to study the effect of prenatal crowding stress (PCS) or maternal deprivation (MD) during infancy on performance in a modified T-maze, an animal model of cognitive functions. Mice pups were divided into two groups : 1) pups of mothers exposed to crowding stress from day 10 to 19 of pregnancy. 2) pups exposed daily to 1-hr deprivation from mothers and littermates from 5 to 22days of age. In PCS mice, success rates in trials were not declined at 7 weeks of age compared to control mice, but declined significantly at 20 weeks of age. the success rates were not declined at 7 and 20 weeks of ages in MD mice, compared with controls. Basal serum corticosteron tended to be increaed in PCS mice, whereas it was decreased in MD mice. The results indicate that PCS affects spatial cognitive behavior in adulthood. It might be related with the excess corticosterone secretion.2). … More Maternal deprivation-induced aggressive behavior in male miceA experiment was carried out study the effect of maternal deprivation in early life on the onset and development of aggressive behavior in male mice in later life. Aggression tests were done at 6, 12, 18 and 24 weeks of age. MD mice revealed higher aggression scores on and after 12 weeks of age. This suggests that aggressive behavior occurs in male mice on and after puberty. The pituitary and adrenal weights of MD mice were decreased and serum corticosterone levels were diminished at 6 and 20 weeks of age. These findings suggest that MD suppresses hypothalamus-pituitary-adrenal (HPA) response. Serum testosterone levels rose in MD male mice at 27 weeks of age. The numbers of 5-HTィイD21AィエD2 and 5-HTィイD22ィエD2 receptor binding sites in the whole brain were not significantly different between MD and non-MD mice at 6 and 42 weeks of age. In conclusion, the onset and development of aggressive behavior in MD male mice is associated with HPA function and testosterone. Further study is needed to evaluate the relationship between aggressiveness and the serotonin system in different brain areas. Less