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Role of Chemokines in Acute Rejection after Rat Lung Transplantation. Interaction with Nitric Oxide and Endothelin.

Role of Chemokines in Acute Rejection after Rat Lung Transplantation. Interaction with Nitric Oxide and Endothelin.
趋化因子在大鼠肺移植后急性排斥反应中的作用。
批准号：
10671257
负责人：
MINAMI Masato
金额：
$1.98万
依托单位：
Osaka University Graduate School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
项目状态：
已结题
起止时间：
1998 至 1999
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671257/
关键词：
Rat lung transplantationNitric OxideiNOSAcute RejectionBAL cell急性拒絶反応ラット肺移植拒絶反応ケモカインNOエンドセリン

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中文摘要
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英文摘要
Rat lung transplantation was performed in isografts and allografts. In isografts, no acute rejection and no significant increase in NO production was identified. In allografts, grade I-II of acute rejection was seen on postoperative day (POD) 3 and grade III on POD 5. NO produced by BAL cells increased on both POD 3 (11.8±2.0 parts per billion [ppb] and POD 5 (115.3±66.9 ppb). There was a highly significant correlation between the level of NO and the severity of AR (p<0.005). BAL cells from allografts expressed iNOS mRNA.Among them, macrophages, lymphocytes and neutrophils were immunostained for iNOS.In conclusion, NO production by BAL cells was detected in the early stages of rejection. Therefore it may serve as a sensitive indicator of AR in lung transplantation.
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T Utsumi: "Nitric oxide production by bronchoalveolar cells during allograft rejection in the rat"Transplantation. 67・12. 1622-1626 (1999)
T Utsumi：“大鼠同种异体移植排斥过程中支气管肺泡细胞产生的一氧化氮”67・12 1622-1626（1999）。
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通讯作者：
T Utsumi. M Minami.: "Nitric oxide production by bronchoalveolar cells during allograft refection in the rat"Transplantation. 67. 1622-1626 (1999)
内海 T.
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