Experimental Studies in vivo for chitosan-bonded bone filling material.

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Three kinds of bone filling materials were prepared by combining powder, including CaO, CaSiOィイD23ィエD2 and hydroxyapatite (HAP), and chitin and chitosan. The proportion of CaO, CaSiOィイD23ィエD2 and HAP was 4.5%, 6.0% and 89.5%. This powder 0.54g(A), 0.67g(B) and 0.80gc were kneaded with chitin and chitosan sol 2.2g and hardened, respectively. These materials were evaluated in the experiment animal and osteoblastic cells. The purpose of this study was to discuss which materials were most desirable for the bone filling materials. In an animal experiment, tissue reactions were similar in each material and were characterized by granulation tissue formation with inflammation. In the osseous tissue, repairs at defected sites (B and C) and direct relationship between material A and revealed that DNA contents and alkaline phosphatase activity in material A were significantly higher that those in control. Results of this study chitosan sol 2.2g, was most effective for the bone formation.