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The relationship between physical activity and anti-oxidant capacity

体力活动与抗氧化能力的关系

基本信息

批准号：
10680023
负责人：
OHKUWA Tetsuo
金额：
$ 2.37万
依托单位：
Nagoya Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

「In 1998 and 1999」A negative correlation was observed between the hydroxyl radical level in liver and the running distance, whereas reduced glutathione level in liver positively correlated with the distance. In addition, the acdvities of glutathione reductase and superoxide dismutase in liver positively correlated with the hydroxyl radical level, suggesting that the anti-oxidant capacity might be induced in consequence of oxidative stress. These results suggest that with higher inducible anti-oxidant capacity may tolerate severer physical exercise, and vice versa rats with higher physical activity may induce higher anti-oxidant capacity. Moreover, it was demonstrated that the endurance training reduced the basal level of hydroxyl radicals significantly in plasma and soleus muscle. In liver and brain a similar tendency was observed, but the differences was not statistically significant. In liver the basal level of GSH increased significantly after training. Slower training with longer duration reduced the basal levels of hydroxyl radical in plasma more markedly than more intense training. These results suggest that endurance training exercise can increase the anti-oxidative capacity in rats. 「In 2000」We observed that the anti-oxidant capacity increases during a selective period in growth, and that voluntary exercise augments the increased at this stage of growh. The effects of exercise on the induction of anti-oxidant capacity should be carefully evaluated, taking consider the effects of growth as shown here. In human study, furthermore, it was cleared that vitamin E supplementation can reduce the leakage of creatine kinase and lactate dehydrogenase activity following the 6 successive days of endurance running. The protective effect of vitamin E against free radicals probably inhibits free-radical-induced muscle damage caused by a sudden large increase in the running distance.

在1998年和1999年，肝脏中的羟自由基水平与跑步距离呈负相关，而肝脏中的还原型谷胱甘肽水平与跑步距离呈正相关。此外，肝脏谷胱甘肽还原酶和超氧化物歧化酶活性与羟自由基水平呈正相关，提示肝脏抗氧化能力可能是氧化应激的结果。这些结果表明，具有较高的诱导抗氧化能力可能会耐受较高的体力活动，反之亦然，较高的体力活动的大鼠可能会诱导较高的抗氧化能力。此外，耐力训练还能显著降低血浆和比目鱼肌中羟自由基的基础水平。在肝脏和大脑中观察到类似的趋势，但差异无统计学意义。在肝脏中，GSH的基础水平在训练后显著增加。较长时间的慢速训练较大强度训练更能降低血浆中羟自由基的基础水平。提示耐力训练运动可提高大鼠抗氧化能力。在2000年我们观察到抗氧化能力在生长的选择性时期增加，并且自愿运动在生长的这个阶段增加。应仔细评估运动对诱导抗氧化能力的影响，并考虑到此处所示的生长影响。此外，在人体研究中，明确了补充维生素E可以减少连续6天耐力跑后肌酸激酶和乳酸脱氢酶活性的泄漏。维生素E对自由基的保护作用可能会抑制自由基引起的肌肉损伤所造成的突然大幅增加的跑步距离。