Effects of exercise training and L-arginine adminstration on fibrinolysis

运动训练和L-精氨酸给药对纤溶的影响

• 批准号: 22500661
• 负责人: OHKUWA Tetsuo
• 金额: $ 2.91万
• 依托单位: Nagoya Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500661/
• 关键词: アルギニン摂取; 運動トレーニング; 血液凝固; 線溶; 加齢; 肥満; 糖尿病; 酸化ストレス; カルボニル化蛋白; 過酸化脂質; L-アルギニン摂取; ラット; ニトロチロシン; カルボニル化タンパク; 運動; L-アルギンン摂取; 血液線溶; タンパク質酸化; 還元型グルタチオン; 老化; 血液の凝固

The present study was performed to evaluate the effects of exercise training and L-arginine administration on the fibrinolysis, blood coagulation and oxidative stress in aged, obese and diabetic rats. The plasminogen activated factor (t-PA and u-PA) significantly increased after exercise training and L-arginine administration. Moreover, thromboxane B2 increased significantly increased after exercise training and L-arginine administration compared with the control rats. The protein oxidation and lipid peroxide significantly decreased, and reduced glutathione (GSH) and glutathione reductase significantly increased after exercise training and L-arginine administration compared with the control rats. This study confirmed that the exercise training and L-arginine administration improved plasminogen activated factor (t-PA and u-PA) and blood coagulation might be due to decrease in oxidative stress in aged, obese and diabetic rats.

本研究旨在探讨运动训练和L-精氨酸对老年、肥胖和糖尿病大鼠纤溶、凝血和氧化应激的影响。血浆纤溶酶原激活因子（t-PA和u-PA）在运动训练和L-精氨酸治疗后显著升高。此外，血栓素B2增加运动训练和L-精氨酸后显着增加与对照组相比。与对照组相比，运动训练和L-精氨酸治疗后，蛋白质氧化和脂质过氧化物水平显著降低，还原型谷胱甘肽（GSH）和谷胱甘肽还原酶水平显著升高。本研究证实，运动训练和L-精氨酸给药改善了老年、肥胖和糖尿病大鼠的纤溶酶原激活因子（t-PA和u-PA）和凝血功能，其机制可能与降低氧化应激有关。

项目成果

ヒト皮膚ガス測定による環境物質の人体への取り込み量の推定(3)

通过人体皮肤气体测量估算进入人体的环境物质量（3）

• 发表时间: 2011
• 作者: 久永真央;津田孝雄;大桑哲男;伊藤宏
• 通讯作者: 伊藤宏

Acetone concentration in gas emanating from tails of diabetic rats

糖尿病大鼠尾部气体中丙酮的浓度

• 发表时间: 2012
• 期刊: Analytical Sciences
• 影响因子: 1.6
• 作者: Kazuaki Yamai;Toshiaki Funada;Tetsuo Ohkuwa;Hiroshi Itoh;Takao Tsuda
• 通讯作者: Takao Tsuda

Gas Biology Research in Clinical Practice

临床实践中的气体生物学研究

• 发表时间: 2011
• 作者: Maruyama K;Zhang K;Maruyama J
• 通讯作者: Maruyama J

Nitric oxide concentrations in gas emanating from the tails of obese rats.

肥胖大鼠尾部散发的气体中一氧化氮的浓度。

• 发表时间: 2013
• 期刊: Redox Report
• 影响因子: 3.8
• 作者: R. Nakanishi;J. Ohwaki;T;Ohkuwa et al.
• 通讯作者: Ohkuwa et al.

Effects of physical-fitness level and anthropometric parameters on postural sway in girls

体能水平和人体测量参数对女孩姿势摇摆的影响

• 发表时间: 2011
• 期刊: Int.J.Fit.
• 作者: K Nishiyama;N Shintaku;T Ohkuwa;T Yamamoto
• 通讯作者: T Yamamoto