Comparison of t-PA and u-PA activities in maximal treadmill and deep-water running

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The purpose of this investigation was to compare urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) levels during maximal treadmill and deep-water running. The maximum heart rate during treadmill running was significantly higher than during deep-water running. The blood lactate concentration was significantly higher in treadmill running than in deep-water running at 5.0 and 7.5 minutes during recovery following exercise (p<0.05). The blood ammonia concentration of the two runs at the 5.0, 7.5, and 10 minutes during recovery differed significantly (p<0.05). At one minute after exercise, the plasma epinephrine and norepinephrine levels were higher in treadmill running compared with that in deep-water running (p<0.05). At one minute after exercise, the t-PA activity was higher in treadmill running compared with that in deep-water running (p<0.05). At one minute after exercise, the u-PA activity was higher in treadmill running compared with that in deep-water running (p<0.05). No significant difference between the two runs was found in total plasminogen activator inhibitor type 1 (PAI-1). In conclusion, maximal treadmill running induced an increase of u-PA and t-PA activities compared to deep-water running. We consider that plasma epinephrine might be stimulating the release of t-PA from endothelial.