Comparison of t-PA and u-PA activities in maximal treadmill and deep-water running

最大跑步机和深水跑中 t-PA 和 u-PA 活性的比较

• 批准号: 13680021
• 负责人: OHKUWA Tetsuo
• 金额: $ 2.62万
• 依托单位: Nagoya Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680021/
• 关键词: Deep-water running; Treadmill running; Epinephrine; PAI-1; t-PA; u-PA; Blood lactate; Blood anmonia; トレッドミル; エピネフリン; 血中乳酸; 陸上トレッドミル運動; 抗酸化物質

The purpose of this investigation was to compare urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) levels during maximal treadmill and deep-water running. The maximum heart rate during treadmill running was significantly higher than during deep-water running. The blood lactate concentration was significantly higher in treadmill running than in deep-water running at 5.0 and 7.5 minutes during recovery following exercise (p<0.05). The blood ammonia concentration of the two runs at the 5.0, 7.5, and 10 minutes during recovery differed significantly (p<0.05). At one minute after exercise, the plasma epinephrine and norepinephrine levels were higher in treadmill running compared with that in deep-water running (p<0.05). At one minute after exercise, the t-PA activity was higher in treadmill running compared with that in deep-water running (p<0.05). At one minute after exercise, the u-PA activity was higher in treadmill running compared with that in deep-water running (p<0.05). No significant difference between the two runs was found in total plasminogen activator inhibitor type 1 (PAI-1). In conclusion, maximal treadmill running induced an increase of u-PA and t-PA activities compared to deep-water running. We consider that plasma epinephrine might be stimulating the release of t-PA from endothelial.

本研究的目的是比较最大跑台和深水跑过程中尿激酶型纤溶酶原激活物（u-PA）和组织型纤溶酶原激活物（t-PA）的水平。在跑台跑步时的最大心率显著高于深水跑步时。运动后恢复期5.0和7.5min跑台运动组血乳酸浓度显著高于深水运动组（P<0.05）。恢复期5.0、7.5和10 min时两次运行的血氨浓度差异显著（p<0.05）。运动后1 min，跑台运动组血浆肾上腺素和去甲肾上腺素水平高于深水运动组（P<0.05）。运动后1 min，跑台运动组t-PA活性高于深水运动组（p<0.05）。运动后1 min，跑台运动组u-PA活性高于深水运动组（p<0.05）。总纤溶酶原激活物抑制物1（派-1）在两次运行之间无显著差异。总之，与深水跑相比，最大跑台跑诱导u-PA和t-PA活性增加。我们认为血浆肾上腺素可能刺激内皮细胞释放t-PA。