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Auditory-vocal-cholinergic pathway in avian song learning

鸟类鸣叫学习中的听觉-发声-胆碱能通路

基本信息

批准号：
10680751
负责人：
SAKAGUCHI Hironobu
金额：
$ 2.11万
依托单位：
DOKKYO UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

1. Male zebra finches learn to imitate a tutor's song through auditory and motor learning. The two main song control nuclei in the bird brain, the higher vocal center (HVC) and the robust nucleus of the archistriatum (RA), receive cholinergic innervation from the ventral paleostriatum (VP) of the basal forebrain which may play a key role in song learning. By injecting neuroanatomical tracers, we found a topographically segregated pathway from nucleus ovoidahs (Ov) to VP that in turn projects in a topographic fashion to HVC and RA.Ov is a major relay in the main ascending auditory pathway. The results suggest that the cholinergic neurons in the VP responsible for song learning are regulated by auditory information from the Ov.2. Auditory-motor interaction is essential for the understanding of avian song learning and maintenance. The HVC nucleus is thought to be the most important station for auditory-motor integration in the avian song system. However, little is known about where and how auditory inputs are conveyed into the HVC.The shelf, a multi-auditory recipient region along the ventral border of the HVC, is thought to be a possible source of auditory inputs to the HVC.Here, we investigated the functional connections between the HVC and surrounding area of the HVC including the shelf in the brain slices, using the real-time optical recording technique. Unexpectedly the electrical stimulation of the shelf region did not induce a signal propagation into the HVC, but stimulation within the HVC propagated strong signals into the shelf. These results suggest that the shelf is the region that receives the output signals from the HVC, rather than a major source of auditory inputs to the HVC.

1.雄性斑胸草雀通过听觉和运动学习来模仿导师的歌声。鸟类大脑中的两个主要鸣唱控制核团，即高级发声中枢（HVC）和原纹状体的鲁棒核（RA），接受来自基底前脑腹侧古纹状体（VP）的胆碱能神经支配，这可能在鸣唱学习中起关键作用。通过注射神经解剖示踪剂，我们发现了一个地形隔离的途径，从卵圆核（Ov）到VP，反过来项目的地形时尚的HVC和RA。Ov是一个主要的中继在主要的上行听觉通路。结果表明，VP负责歌曲学习的胆碱能神经元受到来自Ov的听觉信息的调节。听觉-运动交互作用是理解鸟类鸣唱学习和维持的基础。HVC核被认为是鸟类鸣唱系统中最重要的神经-运动整合站。然而，很少有人知道的听觉输入到HVC的位置和如何传递。货架，沿腹侧边缘的HVC的多个听觉受体区沿着，被认为是一个可能的来源的听觉输入到HVC。在这里，我们研究了HVC和周围区域的HVC包括货架在脑切片的功能连接。出乎意料的是，搁架区域的电刺激没有引起信号传播到HVC中，但是HVC内的刺激将强信号传播到搁架中。这些结果表明，货架是从HVC接收输出信号的区域，而不是HVC的听觉输入的主要来源。