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The volumetric methods in the lesions for radioisotope therapy

放射性同位素治疗病灶的体积法

基本信息

批准号：
10670872
负责人：
KUSAKABE Kiyoko
金额：
$ 1.47万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670872/
关键词：
Dosimetry Radioisotope therapy Functioning mass volume Grave's disease Thyroid cancer Dosimetyr Radioisotope therapy Grave's disease

项目摘要

The estimation of functioning volume in the lesion is an important factor to know the severity of illness. We had been tried to develop the easy method of functioning volume in the organ or lesion tht accumulated radiopharmaceuticals. Clinical evaluation of volumetric analysis following the basic study was performed to estimate the thyroid volume for I-131 therapy in the patients with Graves' hyperthyroidism and to decide the cardiac ejection fraction in the patients with cardiac disease. Of the 57 patients with hyperthyroidism due to Graves' disease who were treated with I-131 was included in this study and compared with the therapeutic effects. The calculated thyroid volume became under 50gram in 87% of patients by scintigraphy with Tc-99m pertechnetate. The patients were classified in three groups according to the absorbed dose, low dose (50-60Gy), middle does (60-80Gy), and high dose (80-90Gy) randomly. And, the relationship between the absorbed dose and therapeutic effect was evaluated. 85% of patiesnts treated with low dose showed euthyroid at 1 year after I-131 therapy. The rate of hypothyroidism was increased in the patients treated with high dose. Low dose therapy was thought to be adequate for leading the patients of Graves' thyrotoxicosis to euthyroidism. The volumetric method by using RI technique was potential use for therapy with I-131. The methodology of heart pool volume for the measurement of cardiac ejection fraction was evaluated in 27 patients with heart disease. The ECG gated SPECT compined with QGS program was used for the measurement of the end diastolic volume and end systolic volume of ventricle and compared with the results of coronary angiongraphy. The ejection fractions of left ventricle was well correlated with the levels measured by cardiac catheterization (y = 1.27X+9.25, r = 0.962). It was recognized that the volumetric method by ECG gated SPECT combined with QGS program become a promising method of cadiac function.

病变功能容积的估计是了解病变严重程度的重要因素。我们一直在尝试开发一种简单的方法来测量累积放射性药物的器官或病变的功能体积。在基础研究后进行了体积分析的临床评价，以估计I-131治疗Graves'甲亢患者的甲状腺体积，并确定心脏病患者的心脏射血分数。对57例Graves病甲亢患者用碘-131治疗，并进行疗效比较。99 mTc-高锝酸盐甲状腺造影87%的患者甲状腺体积小于50 g。按吸收剂量随机分为低剂量组（50- 60 Gy）、中剂量组（60- 80 Gy）和高剂量组（80- 90 Gy）。并对吸收剂量与疗效的关系进行了评价。小剂量治疗组1年后甲状腺功能正常率为85%。高剂量组甲减发生率明显增高。认为小剂量治疗足以使Graves'甲亢患者甲状腺功能正常。利用放射性核素技术的容积法是碘-131治疗的潜在方法。本文对27例心脏病患者的心池容积测定法进行了评价。采用心电门控SPECT结合QGS程序测量心室舒张末期容积和收缩末期容积，并与冠状动脉造影结果进行比较。左室射血分数与心导管测量值呈良好的相关性（y = 1.27X+9.25，r = 0.962）。心电门控SPECT容积法结合QGS程序是一种很有前途的心功能检测方法。