Evaluation of improved therapeutic effect of radioisotope therapy combining targeted inhibition of amino acid transporter.

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Correlation of 18^F-AMT uptake and cellular growth activity evaluated by Ki-67 labeling index was assessed in patients with head and neck cancer. As a result, significant correlation of both indexes was confirmed. As for 131^I-MIBG therapy, the early therapeutic response by the measurement of serum catecholamine 1 week after injection of 131^I-MIBG was assessed and serum catecholamine is proved to be significantly related with better response. Furthermore, diagnostic utility of FDG-PET/CT comparing with 123I-MIBG scintigraphy and X-ray CT in the evaluation of therapeutic effect of 131^I-MIBG was assessed and it is confirmed that FDG-PET/CT is useful in the evaluation of therapeutic response of 131^I-MIBG in malignant pheochromocytoma.