Evaluation of improved therapeutic effect of radioisotope therapy combining targeted inhibition of amino acid transporter.

评估放射性同位素治疗结合靶向抑制氨基酸转运蛋白的改善疗效。

• 批准号: 21591544
• 负责人: HIGUCHI Tetsuya
• 金额: $ 2.66万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591544/
• 关键词: アミノ酸輸送担体(LAT1); 神経内分泌腫瘍; F-18標識αメチルタイロシン; ポジトロンCT; RI内用療法

Correlation of 18^F-AMT uptake and cellular growth activity evaluated by Ki-67 labeling index was assessed in patients with head and neck cancer. As a result, significant correlation of both indexes was confirmed. As for 131^I-MIBG therapy, the early therapeutic response by the measurement of serum catecholamine 1 week after injection of 131^I-MIBG was assessed and serum catecholamine is proved to be significantly related with better response. Furthermore, diagnostic utility of FDG-PET/CT comparing with 123I-MIBG scintigraphy and X-ray CT in the evaluation of therapeutic effect of 131^I-MIBG was assessed and it is confirmed that FDG-PET/CT is useful in the evaluation of therapeutic response of 131^I-MIBG in malignant pheochromocytoma.

在头颈部癌患者中评估了18^F-AMT摄取与Ki-67标记指数评价的细胞生长活性的相关性。结果表明，两个指标之间存在显著的相关性。在131^I-MIBG治疗中，通过测定注射131^I-MIBG后1周的血清儿茶酚胺来评估早期治疗反应，证明血清儿茶酚胺与较好的反应显著相关。进一步评价了FDG-PET/CT在评价131^I-MIBG疗效中的诊断价值，并与123 I-MIBG血管造影和X线CT进行了比较，证实了FDG-PET/CT在评价131^I-MIBG治疗恶性嗜铬细胞瘤疗效中的价值。

项目成果

肺がんのPET診断

肺癌的PET诊断

• 发表时间: 2010
• 作者: 宮下剛、樋口徹也;他;樋口徹也
• 通讯作者: 樋口徹也

Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer

• DOI: 10.1111/j.1349-7006.2008.01077.x
• 发表时间: 2009-04-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Kaira, Kyoichi;Oriuchi, Noboru;Mori, Masatomo
• 通讯作者: Mori, Masatomo

Dual functional molecular imaging probe targeting CD20 with PET and optical imaging

• DOI: 10.3892/or_00000413
• 发表时间: 2009-07-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Paudyal, Pramila;Paudyal, Bishnuhari;Endo, Keigo
• 通讯作者: Endo, Keigo

18F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with 18F-FDG PET and immunohistochemistry

• DOI: 10.1007/s12149-010-0398-2
• 发表时间: 2010-10-01
• 期刊: ANNALS OF NUCLEAR MEDICINE
• 影响因子: 2.6
• 作者: Miyashita, Go;Higuchi, Tetsuya;Endo, Keigo
• 通讯作者: Endo, Keigo

口腔腫瘍術前症例における頚部リンパ節転移の診断におけるFAMT-PET追加の有用性;FDG-PETとの比較

FAMT-PET与FDG-PET在口腔肿瘤术前诊断颈部淋巴结转移中的应用

• 发表时间: 2011
• 作者: 宮下剛;樋口徹也
• 通讯作者: 樋口徹也