Insulin Resistance in Rehabilitation Medicine
康复医学中的胰岛素抵抗
基本信息
- 批准号:10838030
- 负责人:
- 金额:$ 1.86万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It has been reported that asymptomatic myocardial ischemia is not a rare complication in patients with ischemic stroke. There is empirical evidence showing that asymptomatic myocardial ischemia in ischemic stroke patients derives from insulin resistance, because decreased physical activity and obesity are important background factors in insulin resistance. Furthermore, stroke patients often have a background of insulin resistance on account of their motor impairment.The purpose of this study was 1) to show the incidence of insulin resistance in Japanese patients with ischemic stroke, and 2) to investigate the relationship between insulin resistance and physical activity and obesity in these patients. The subjects were 46 ischemic stroke patients with hypertriglyceridemia (serum triglyceride level above 150 mg/dl). Insulin resistance was evaluated through a 75-g oral glucose tolerance test (75gOGTT), and was judged to be positive if the fasting blood insulin level was above 1OμU/ml or the blood insulin level after two hours of 75gOGTT was above 65 μU/ml. Physical activity was assessed from the walking ability and a patient was evaluated as active if capable of independent walking in the ward or at home. Obesity was classified by the body mass index (BMI).Insulin resistance was positive in 19 subjects (41.3%), and the BMI in these patients was larger than in cases without insulin resistance (25.1 VS 22.0). It was concluded that obesity is an important factor in the occurrence of insulin resistance in Japanese patients with ischemic stroke.
据报道,无症状心肌缺血并不是缺血性卒中患者的罕见并发症。有经验证据表明,缺血性卒中患者的无症状心肌缺血源于胰岛素抵抗,因为体力活动减少和肥胖是胰岛素抵抗的重要背景因素。本研究的目的是:1)了解日本缺血性卒中患者的胰岛素抵抗发生率,2)研究这些患者的胰岛素抵抗与体力活动和肥胖的关系。研究对象为46例伴有高甘油三酯血症(血清甘油三酯水平高于150 mg/dl)的缺血性脑卒中患者。采用75 g口服葡萄糖耐量试验(75 gOGTT)评价胰岛素抵抗,以空腹血胰岛素水平> 10 μU/ml或75 gOGTT后2 h血胰岛素水平> 65 μU/ml为阳性。根据行走能力评估体力活动,如果患者能够在病房或家中独立行走,则将其评价为活跃。肥胖按体重指数(BMI)分类,胰岛素抵抗阳性者19例(41.3%),BMI高于非胰岛素抵抗者(25.1VS22.0)。结论:肥胖是日本缺血性卒中患者发生胰岛素抵抗的重要因素。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
間嶋 満他: "運動障害者における心疾患への対応-不整脈が問題となる場合-" 臨床リハ. 8(4). 306-310 (1999)
Mitsuru Mashima 等人:“应对运动障碍患者的心脏病 - 当心律失常成为问题时 -”临床康复 8(4)。
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- 影响因子:0
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間嶋満: "運動障害者におけるインスリン抵抗性-高インスリン血症を有する症例における合併頻度とリハビリテーション医学における位置ずけ"総合リハ. 26(12). 1189-1192 (1998)
Mitsuru Mashima:“运动障碍患者的胰岛素抵抗 - 高胰岛素血症病例的并发症频率及其在康复医学中的地位”《综合康复》26(12)。
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間嶋 満: "運動障害者における心疾患への対応.不整脈が問題となる場合"臨床リハ. 8・4. 306-310 (1999)
Mitsuru Mashima:“应对运动障碍患者的心脏病。当心律失常成为问题时”临床康复 8・4。
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MAJIMA Mitsuru其他文献
MAJIMA Mitsuru的其他文献
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{{ truncateString('MAJIMA Mitsuru', 18)}}的其他基金
Relationship between visceral fat,adipocytokines and insulin resistance in stroke patients,and effect of walking on improvement of insulin resistance, visceral fat and adipocytokines
脑卒中患者内脏脂肪、脂肪细胞因子与胰岛素抵抗的关系及步行对胰岛素抵抗、内脏脂肪和脂肪细胞因子的改善作用
- 批准号:
18500419 - 财政年份:2006
- 资助金额:
$ 1.86万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Effect of endurance exercise on insulin resistance in patients with motor impairment
耐力运动对运动障碍患者胰岛素抵抗的影响
- 批准号:
15500380 - 财政年份:2003
- 资助金额:
$ 1.86万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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