Study on the mechanical properties of tibial cartilage and subchondral bone

胫骨软骨及软骨下骨力学性能研究

• 批准号: 11650110
• 负责人: SAKAMOTO Makoto
• 金额: $ 2.05万
• 依托单位: NIIGATA UNIVERSITY (2000-2001)Niigata College of Technology (1999)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11650110/
• 关键词: Biomechanics; Strength of materials; Cartilage; Cortical bone; Indentation test; Ultrasonic; Elastic modulus; Microhardness; 押し込み実験; 微小硬さ試験

The subchondral cortex lies immediately below the thin layer of calcified cartilage. It is a layer dense, stiff, cortical bone. In the mature human, it forms a closed cap supporting the cartilage on one side and supported by the cancellous bone on the other. Unanswered questions regarding the etiology of primary osteoarthritis, as well as the recent interest in the use of finite element analysis in the study of knee joint, suggest a need for detailed data on the mechanical properties of subchondral bone as a specific structural entity. However, only limited information is presently available on mechanical property of subchondral bone because of the lack of appropriate local elastic property measuring method.In this study we measured the elastic modulus of human proximal tibial subchondral bone and articular cartilage in the osteoarthritis of knee joint using the scanning acoustic microscope (SAM), peripheral quantitative computed tomography (pQCT) and the indentation method. Proximal tibial plates were taken from human tibiae of osteoarthrosis joints. Disc-shaped specimens were machined from standardized locations on these plates with a core drill. The axes of the specimens were parallel to the long axis of tibia. The distribution of cartilage thickness was measured by needle method. Following is an example results obtain through this experiment. There is a serious damage on the cartilage from the center to posterior of medial condyle and the subchondral boneis exposed. In the medial condyle, the density and the elastic modulus of the subchondral bone is higher at posterior area than anterior.

软骨下皮质位于钙化软骨薄层的正下方。它是一层致密、坚硬的皮质骨。在成熟的人体中，它形成一个封闭的帽，一侧支撑软骨，另一侧由松质骨支撑。关于原发性骨关节炎病因学的未解答问题，以及最近对在膝关节研究中使用有限元分析的兴趣，表明需要关于软骨下骨作为特定结构实体的机械性能的详细数据。然而，由于缺乏合适的局部弹性性能测量方法，目前关于软骨下骨力学性能的信息有限。在本研究中，我们利用扫描声学显微镜（SAM）、外周定量计算机断层扫描（pQCT）和压痕法测量了膝关节骨关节炎中人体近端胫骨软骨下骨和关节软骨的弹性模量。近端胫骨板取自骨关节的人类胫骨。使用空心钻从这些板上的标准化位置加工出圆盘状样本。标本的轴线平行于胫骨的长轴。采用针法测量软骨厚度的分布。以下是通过该实验获得的示例结果。内侧髁中心至后部软骨损伤严重，软骨下骨外露。在内侧髁中，软骨下骨的密度和弹性模量后部区域高于前部区域。

项目成果

山崎安克: "脛骨膝関節近傍組織の力学的特性評価"日本機械学会12回バイオエンジニアリング講演会・講演論文集. 99-37. 109-110 (2000)

Yasukatsu Yamazaki：“胫骨膝关节附近组织的机械性能评估”日本机械工程师学会第 12 届生物工程会议记录 99-37 (2000)。

Makoto Sakamoto: "Estimation of local elastic modulus of hard tissues using Microhardness"Journal of Japanese Society for Clinical Biomechanics. vol. 22. 51-57 (2001)

Makoto Sakamoto：“使用显微硬度估计硬组织的局部弹性模量”日本临床生物力学学会杂志。

Katsuhiro Nagai: "Mechanical evaluation of bone property using minute specimens"The 13th Bioengineering Conference, 2000 Annual Meeting of BE D/JSME. vol. 00-37. 106-107 (2001)

Katsuhiro Nagai：“利用微小样本对骨特性进行机械评估”第13届生物工程会议，BE D/JSME 2000年年会。

坂本 信: "Prediction of elastic modulus of cortical bone using microhardness testing"Theoretical and Applied Mechanics. 50. 97-101 (2001)

Shin Sakamoto：“使用显微硬度测试预测皮质骨的弹性模量”理论与应用力学。50. 97-101 (2001)

Hiroshi Takahashi: "An evaluation of mechanical properties of whole bone using PQCT"Journal of Japanese Society for Clinical Biomechanics. vol. 21. 409-414 (2000)

Hiroshi Takahashi：“使用 PQCT 评估全骨的机械性能”日本临床生物力学学会杂志。