The study of pathophysiological mechanism for the subcortical dementia- an evaluation using event-related potentials tomography

为了评价皮层下痴呆的病理生理变化，我们分析了事件相关电位的电场。作为基础研究，我们在听觉研究中考察了任务相关性和P3a成分新颖性的影响。我们的数据表明，新颖性P300的特征可能取决于平行加工过程中可用于新颖性刺激的心理资源。在基础研究的基础上，采用听觉奇球和四音范式评价血管性痴呆（VaD）患者的信息加工障碍特征。提示轻度VaD患者的心理功能障碍特征不仅与信息处理速度异常有关，还与心理资源配置异常有关。第三项研究是帕金森病作为皮层下痴呆的病理生理机制的评估。应用新刺激和目标刺激产生的事件相关电位图检测帕金森病患者的心理转换（持续性）功能障碍。我们的研究结果表明，心理转换减少导致pdp缺乏新颖性P3习惯，这与基于额叶和基底神经节功能障碍的学习障碍有关。最后，我们研究了听觉感官输入的早期信息加工是否会阻碍pdp。结果表明，PDP在听觉输入信息的自动加工和控制加工方面均存在功能障碍。

To evaluate the pathophysiological changes in subcortical dementia, electrical filed of the event-related potentials were analyzed. As the fundamental study, we examined the effect of task relevance and the novelty of P3a components in an auditory study. Our data suggest that the characterization of novelty P300 may depend on the mental resources that can be devoted to novel stimuli during parallel processing.After the fundamental study, we evaluated the characteristics of information processing disturbance in patients with vascular dementia (VaD) using auditory oddball and 4-tone paradigms. The data suggest that the characteristics of mental dysfunction in mild VaD patients do not only depend on abnormal information processing speed but also abnormal mental resource allocation.The 3rd study is the evaluation of pathophysiological mechanism for the Parkinson's disease as subcortical dementia. Event-related potentials topography produced by novel and target stimuli was used to detect dysfunction of mental switching (perseveration) in Parkinson's disease Parkinson's disease patients (PDPs). Our findings suggest that decreased mental switching causes lack of novelty P3 habituation in PDPs and that this is related to learning disability based on dysfunction of frontal lobe and basal ganglia.Finally, we investigated whether early information processing for auditory sensory input would be hindered in PDPs. The data indicated that there are dysfunction both of automatic and controlled processing in the information processing for auditory sensory input in the PDP.