Basic research objected to establish the highly qualified assessment of hepatic reserve function by utilizing new molecular marker localized in liver

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The researches were composed of three kinds of contents as follows : (1) the studies about low localized molucules utilized for the assessments of hepatic function, (2) the regulation on isolation, identification and proliferation of hepatic stem cells recognized to have key roles and (3) the possibility of gene-transfected hepatocyte or heparic stem cell on the treatment for hepatic dysfunction. Our results showed (1) the logical significance of asialoglycoprotein receptor count method and the distribution of adhesion molecules (especially claudins) on hepatic cell function, (2) successful modification of hepatic stem cells in vitro, and (3) the clinical capability by the cell transplantation utilized gene-transfected hepatocytes or fresh hepatic stem cells.