Cerebral Functionation and Genetic Risk Factor in Dementia of Lewy body Type and Alzheimer type

路易体型和阿尔茨海默型痴呆的脑功能和遗传危险因素

• 批准号: 11670927
• 负责人: KAWAKATSU Shinobu
• 金额: $ 2.24万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670927/
• 关键词: dementia of lewy body type; dementia of alzheimer type; apolipoprotein E; single photon emission computed tomography (SPECT); 脳血流量; 局所脳血流量; MRI

1. Regional cerebral blood flow (rCBF) was measured using Xenon-133 and single photon emission tomography (SPECT) in 28 patients with dementia of lewy body type (DLB), 49 patients with dementia of Alzheimer type (AD) and 30 age-matched controls. (1) Global cerebral blood flow of DLB was significantly decreased compared to AD and controls. This may reflect dysfunction of ascending reticular activating system of the brain stem in DLB. (2) Although decreased rCBF in the temporoparietal region was seen both in DLB and AD, additional reduction of rCBF in the occipital region was a characteristic finding of DLB. This may relate to visual hallucination in DLB.2. Phenotype of apolipoprotein E was determined in DLB, AD and controls. The frequency of epsilon 4 allele was 0.17 in DLB, 0.25 in AD and 0.07 in control. Although it did not reach statistical significant level, DLB had intermediate epsilon 4 allele frequency between AD and control.3. It is concluded that DLB and AD are the overlapping disease in respect of functional brain imaging and genetic risk factors.

1.应用~（133）氙和单光子发射断层显像（SPECT）对28例Lewy体型痴呆（DLB）、49例Alzheimer型痴呆（AD）和30例正常对照者的局部脑血流量（rCBF）进行了测定。(1)与AD和对照组相比，DLB的全脑血流量显著降低。这可能反映了DLB时脑干上行网状激活系统的功能障碍。(2)虽然在DLB和AD中均观察到颞顶区域的rCBF降低，但枕骨区域的rCBF额外降低是DLB的特征性发现。这可能与DLB中的视幻觉有关。测定DLB、AD和对照组的载脂蛋白E表型。DLB、AD和对照组的等位基因频率分别为0.17、0.25和0.07。DLB等位基因频率介于AD和对照组之间，但未达到统计学显著水平.结论DLB与AD在脑功能成像和遗传危险因素方面是重叠的疾病。

项目成果

Kato K., Wada T., Kawakatsu S., Otani K.: "Improvement of both psychotic symptoms and Parkinsonism in a case of dementia with Lewy bodies by the combination therapy of risperidone and L-DOPA"Prog Neuropsychopharmacol Biol Psychiatry. 26(1). 201-3 (2002)

Kato K.、Wada T.、Kawakatsu S.、Otani K.：“利培酮和 L-DOPA 联合治疗可改善路易体痴呆病例的精神病症状和帕金森症”Prog Neuropsychopharmacol Biol Psychiatry。

川勝 忍: "老年期の脳器質性精神障害"最新精神医学.

Shinobu Kawakatsu：“老年器质性精神障碍”最新精神病学。

Chui DH, Dobo E, Makifuchi T, Akiyama H, Kawakatsu S, et al.: "Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling"J Alzheimers Dis.. 3. 231-239 (2001)

Chui DH、Dobo E、Makifuchi T、Akiyama H、Kawakatsu S 等人：“阿尔茨海默病中的凋亡神经元经常显示细胞内 Abeta42 标记”J Alzheimers Dis.. 3. 231-239 (2001)

川勝 忍: "臨床精神医学講座第S10巻,精神科臨床における画像診断(分担執筆)"中山書店. 228-240 (2000)

川胜忍：《临床精神病学教程第S10卷，临床精神病学影像诊断（合着）》中山书店228-240（2000年）。

Kato K, Wada T, Kawakatsu S, et al.: "Improvement of both psychotic symptoms and Parkinsonism in a case of dementia with Lewy bodies by the combination therapy of risperidone and L-DOPA"Prog Neuropsychopharmacol Biol Psychiatry. 26. 201-203 (2002)

Kato K、Wada T、Kawakatsu S 等人：“利培酮和 L-DOPA 联合治疗可改善路易体痴呆病例的精神病症状和帕金森症”Prog Neuropsychopharmacol Biol Psychiatry。