Investigation on the selective loss of large neurons in the neostriatum in senile dementia of Alzheimer type

对阿尔茨海默病(AD)和阿尔茨海默型老年期痴呆(SDAT)新纹状体的退变过程进行了研究：(1)定量研究显示大神经元选择性减少，小神经元保留。(2)进行性核上性麻痹(PSP)也有类似表现。(3)形态学观察显示，两种疾病的大神经元弥漫性均匀减少。(4)两种疾病残留的新纹状体大神经元均表现为神经原纤维缠结(NFT)。在超微结构上，AD/SDAT的NFT_S由扭曲的小管组成，PSP的NFT_S由直管组成。(5)AD/SDAT新纹状体大神经元的减少与Meynert基底核神经元的丢失有关，而PSP与新纹状体大神经元的减少无关。

The degenerating processes of the neostriatum in Alzheimer's disease (AD) and senile dementia of alzheimer type (SDAT) were investigated.(1) Quantitative study revealed selective decrease of the large neurons and preservation of the small neurons.(2) Similar findings were observed in progressive supranuclear palsy (PSP).(3) Topographic investigation showed diffuse and uniform decrease of the large neurons in both diseases.(4) The remaining large neostriatal neurons in both diseases show neurofibrillary tangles (NFT). Ultrastructurally the NFT_s in AD/SDAT were composed of twisted tubules and the NFT_s in PSP were consisted with straight tubules.(5) The decrease of the large neurons in the neostriatum was correlated to loss of neurons in the basal nucleus of meynert in AD/SDAT, but not in PSP.