Investigation on the selective loss of large neurons in the neostriatum in senile dementia of Alzheimer type

阿尔茨海默型老年痴呆新纹状体大神经元选择性丢失的研究

• 批准号: 62570363
• 负责人: OYANAGI Kiyomitsu
• 金额: $ 1.34万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570363/
• 关键词: Alzheimer's disease; Senile dementia; Progressive Supranuclear Palsy; Neostriatum; Large neuron; Cholinergic neuron; Neurofibrillary tangle; コリン作動性ニューロン; アルツハイマー型老年痴呆; 進行性核上性麻痺; 神経原線維変化

The degenerating processes of the neostriatum in Alzheimer's disease (AD) and senile dementia of alzheimer type (SDAT) were investigated.(1) Quantitative study revealed selective decrease of the large neurons and preservation of the small neurons.(2) Similar findings were observed in progressive supranuclear palsy (PSP).(3) Topographic investigation showed diffuse and uniform decrease of the large neurons in both diseases.(4) The remaining large neostriatal neurons in both diseases show neurofibrillary tangles (NFT). Ultrastructurally the NFT_s in AD/SDAT were composed of twisted tubules and the NFT_s in PSP were consisted with straight tubules.(5) The decrease of the large neurons in the neostriatum was correlated to loss of neurons in the basal nucleus of meynert in AD/SDAT, but not in PSP.

本文观察了Alzheimer病（AD）和Alzheimer型老年痴呆（SDAT）患者新纹状体的变性过程。(1)定量研究显示大神经元的选择性减少和小神经元的保存。(2)在进行性核上性麻痹（PSP）中也观察到类似的结果。(3)拓扑学研究显示两种疾病中大神经元的弥漫性和均匀性减少。(4)两种疾病中剩余的大的新纹状体神经元显示神经元缠结（NFT）。超微结构上，AD/SDAT的NFT_s由扭曲的小管组成，PSP的NFT_s由平直的小管组成。(5)在AD/SDAT中，新纹状体中大神经元的减少与Meynert基底核中神经元的丢失相关，但在PSP中不相关。

项目成果

小柳清光: Brain Resarch.

小柳清光：大脑研究。

Kiyomitsu Oyanagi: "Selective involvement of large neurons in the neostriatum of Alzheimer's disease and senile dementia: a morphometric investigation" Brain Research. 411. 205-211 (1987)

Kiyomitsu Oyanagi：“阿尔茨海默病和老年痴呆症新纹状体中大神经元的选择性参与：形态测量研究”大脑研究。

Kiyomitsu Oyanagi: "Selective loss of large neostriatal neurons in Alzheimer's disease and progressive supranuclear palsy: a topographic and ultrastructural study" Brain Research.

Kiyomitsu Oyanagi：“阿尔茨海默病和进行性核上性麻痹中大新纹状体神经元的选择性丧失：地形和超微结构研究”大脑研究。

小柳清光: Clinical Neuropathology. 6. 71-79 (1987)

小柳清光：临床神经病理学。6. 71-79 (1987)

小柳清光: Brain Research. 411. 205-211 (1987)

小柳清光：大脑研究 411. 205-211 (1987)