Investigation on the selective loss of large neurons in the neostriatum in senile dementia of Alzheimer type

本文观察了Alzheimer病（AD）和Alzheimer型老年痴呆（SDAT）患者新纹状体的变性过程。(1)定量研究显示大神经元的选择性减少和小神经元的保存。(2)在进行性核上性麻痹（PSP）中也观察到类似的结果。(3)拓扑学研究显示两种疾病中大神经元的弥漫性和均匀性减少。(4)两种疾病中剩余的大的新纹状体神经元显示神经元缠结（NFT）。超微结构上，AD/SDAT的NFT_s由扭曲的小管组成，PSP的NFT_s由平直的小管组成。(5)在AD/SDAT中，新纹状体中大神经元的减少与Meynert基底核中神经元的丢失相关，但在PSP中不相关。

The degenerating processes of the neostriatum in Alzheimer's disease (AD) and senile dementia of alzheimer type (SDAT) were investigated.(1) Quantitative study revealed selective decrease of the large neurons and preservation of the small neurons.(2) Similar findings were observed in progressive supranuclear palsy (PSP).(3) Topographic investigation showed diffuse and uniform decrease of the large neurons in both diseases.(4) The remaining large neostriatal neurons in both diseases show neurofibrillary tangles (NFT). Ultrastructurally the NFT_s in AD/SDAT were composed of twisted tubules and the NFT_s in PSP were consisted with straight tubules.(5) The decrease of the large neurons in the neostriatum was correlated to loss of neurons in the basal nucleus of meynert in AD/SDAT, but not in PSP.