Research on the common signal transduction bases of mood, motivation and memory related disorders

情感障碍和精神分裂症是两种最重要的内源性精神疾病。最近，几位研究人员提出，这两种疾病之间存在共同和重叠的症状，特别是在抑郁症和精神分裂症的阴性症状方面。我们检测了单相抑郁症和慢性精神分裂症患者死后额叶皮质的两个第二信使系统[腺苷环化酶(AC)活性、磷脂酶C(PLC)]的产生活性，并与对照组进行了比较。抑郁症患者基础AC活性显著降低，而锰刺激的AC活性与对照组相比有下降趋势。与抑郁症相比，精神分裂症患者的基础AC活动和激发的AC活动与正常对照组无差异。另一方面，抑郁症和精神分裂症患者5-羟色胺刺激的PLC活性与对照组相比显著增加。此外，与对照组相比，阿尔茨海默病患者大脑中AC-I和AC-II亚型的免疫反应性显著降低。这些结果表明，第二信使的生产活动障碍与抑郁症、精神分裂症和阿尔茨海默病的病理生理有关，并与情绪、动机和记忆障碍有关。

Affective disorder and schizophrenia are the two most important endogenous psychiatric diseases. Recently several researchers have suggested that there are common and overlapping symptoms between these two disorders, especially in terms of depression and negative symptoms of schizophrenia.. We examined the productive activity of two second messengers systems [adenylyl cyclase (AC) activity phospholipase C (PLC)] in membrane preparations from postmortem frontal cortex of monopolar depressive patients and chronic schizophrenia in comparison with control subjects. Basal AC activity was significantly decreased in depressives, and Mn^<2+>-stimulated AC activity had a tendency to decline compared to controls. In contrast to depressions, there were no differences in basal and Mn^<2+> stimulated AC activity between schizophrenia and controls. In the other hand, 5-HT-stimulated PLC activity as significantly increased in both depressives and schizophrenia compared to controls. Additionally, the immunoreactivities of AC-I and AC-II subtypes showed significant decreases in Alzheimer disease brains compared to controls. These results indicated that the impairment in productive activity of second messengers is related to the pathophysiology of depression, schizophrenia and Alzheimer disease related with of mood, motivation and memory disturbances.