Stress Vulnerability and Immune Function: Psycho-Neuro-Immunological Function in Eating Disorders and Other Mental Disorders

压力脆弱性和免疫功能：饮食失调和其他精神障碍中的心理神经免疫功能

• 批准号: 11670962
• 负责人: NAGATA Toshihiko
• 金额: $ 2.24万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670962/
• 关键词: Bulimia Nervosa; Eating Disorders; Social Anxiety Disorder; Lymphocyte Prolilerative Response; Lymphocyte Subset; Stress; Lytokine; Psicho-Neuro-Immunology; social anxiety disorder; bulimia neruosa; lymphosyte subset; Lymphocyte proliferative r

Subjects consisted of 20 female patients with bulimia nervosa (BN), 9 patients (6 were male) with social anxiety disorder (SAD) and 20 controls (6 were male). All were provided written informed consent. There were no significant differences in age or Body Mass Index among these groups. There were no significant differences in lymphocyte subsets such as CD4/CD8 ratio among these three groups. However, lymphocyte proliferative response with PHA/control ratio (Stimulation Index; SI) in BN patients was significantly lower than that in control women. SI was also significantly related with Beck's Depression Inventory score(r=-.56, p=.001), Trait subscale of State-Trait Anxiety Inventory (rs=-.58, p<.001), Emotion subscale of Coping Inventory for Stressful Situations (r=-.58, p<.001). In addition, lower SI in BN patients (N=9) significantly improved according to progress of treatment. SI in SAD patients were also significantly lower than that in C group (87±35 vs. 328±269, t=3.9, p=.001).

研究对象包括20例女性神经性贪食症（BN）患者，9例（6例男性）社交焦虑障碍（SAD）患者和20例（6例男性）对照组。所有患者均提供了书面知情同意书。这些组之间的年龄或体重指数没有显著差异。三组间淋巴细胞亚群CD 4/CD 8比值无显著性差异。然而，BN患者的淋巴细胞增殖反应与PHA/对照比率（刺激指数; SI）显着低于对照妇女。SI还与贝克抑郁量表评分（r=-.56，p=.001）、状态-特质焦虑量表的特质子量表（rs=-.58，p<.001）、压力情境应对量表的情绪子量表（r=-.58，p<.001）显著相关。此外，BN患者（N=9）的低SI根据治疗进展显著改善。SAD患者的SI也明显低于C组（87±35 vs. 328±269，t=3.9，p=.001）。

项目成果

Nagata, T. et al.: "Open trail of milnacipran for Taijin Kyoufusho in Japanese patients with social anxiety disorder"Int J Psych Clin Pract. (in press).

Nagata, T. 等人：“米那普仑在日本社交焦虑症患者中用于 Taijin Kyoufusho 的开放试验”Int J Psych Clin Pract。

Nagata, T. et al.: "Repetitive self-mutilation among Japanese eating disorder patients with drug use disorder: Comparison with patients with methamphetamine use disorder."J New Ment Dis.. (in press).

Nagata, T. 等人：“患有药物使用障碍的日本饮食失调患者中的重复自残：与甲基苯丙胺使用障碍患者的比较。”J New Ment Dis..（出版中）。

Nagata T. et al.: "Drug use disorders in Japanese eating disorder patients"Psychiatry Res.. 109. 181-191 (2002)

Nagata T.等：“日本饮食失调患者的药物使用障碍”Psychiatry Res.. 109. 181-191 (2002)

Nagata T. et al.: "Physical and sexual abuse histories in patients with eating disorders: a comparison of Japanese and American patients"Psychiatry Clin. Neurosci.. 55. 333-340 (2001)

Nagata T.等人：“饮食失调患者的身体和性虐待史：日本和美国患者的比较”精神病学临床。

Nagata,T. et al: "Multi-impulsivity of Japanese patents with eating disorders : primary and secondary impulsuity"Psychiatry Research. 94. 239-250 (2000)

永田，T.