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High frequency Stinulation fo reduce muscle fatigue in functional electhiccl Sfimu lation

功能性电刺激中减少肌肉疲劳的高频刺激

基本信息

批准号：
11671412
负责人：
SHIMADA Yoichi
金额：
$ 1.47万
依托单位：
Akita Unuversity
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671412/
关键词：
FES Muscle fatigue High frequency Stinulation

项目摘要

We evaluated the effects of high frequency electrical stimulation for preventing acute muscle atrophy after spinal cord transection in rats. The lesser fiber diameters from type 1, 2A and 2B muscle fibers were measured. In another assessment, maximal contraction force was measured. The muscle force produced at 20, and 100Hz was expressed as increasing values (IV) in tetanic force. In the comparison between non-stimulated and stimulated Tibialis Anterior (TA) muscles, the atrophy of type 1 fibers (p < .01) and type 2B fibers (p < .05) at both stimulated levels and of type 2A fibers at 100Hz level (p < .05) were preventedby therapeutic electrical stimulation (TES). There were significant differences in the size of muscle fiber diameter between non-stimulated and stimulated muscles at 100 Hz in type 2A and, markedly, in type 2B. The increasing value of muscle force was significantly greater at 100Hz than at 20Hz (p < .05). No significant histological differences were observed between high and low frequency stimulated fibers of any of the three muscle types. We concludes that acute atrophy of muscle fibers was more effectively prevented by high (100Hz) frequency stimulation than no or low (20Hz) frequency stimulation, and the increasing value of muscle force was significantly greater at high frequency stimulation than low frequency stimulation, suggesting that future studies, including the clinical application of high frequency stimulation to acute spinal cord injury, should be conducted.

我们评估了高频电刺激对预防大鼠脊髓横断后急性肌肉萎缩的作用。测量了1型、2A型和2B型肌纤维的较小纤维直径。在另一项评估中，测量了最大收缩力。在20和100 Hz下产生的肌肉力量表示为强直力的增加值（IV）。在未刺激和刺激的胫骨前肌（TA）之间的比较中，治疗性电刺激（TES）防止了在两个刺激水平下的1型纤维（p < .01）和2B型纤维（p < .05）以及在100Hz水平下的2A型纤维（p <.05）的萎缩。2A型和2B型在100 Hz频率下，非刺激和刺激肌肉之间的肌纤维直径大小存在显著差异。100Hz时肌肉力量的增加值显著大于20Hz时（p <0.05）。没有显着的组织学差异之间观察到的任何三种肌肉类型的高频和低频刺激的纤维。结论：高频（100 Hz）刺激较无或低频（20 Hz）刺激能更有效地防止急性肌纤维萎缩，且高频刺激的肌力增加值明显大于低频刺激，提示今后应开展高频刺激在急性脊髓损伤中的临床应用等研究。