High frequency Stinulation fo reduce muscle fatigue in functional electhiccl Sfimu lation

我们评价了高频电刺激预防大鼠脊髓横断后急性肌萎缩的效果。测量了1型、2A型和2B型肌纤维的较小纤维直径。在另一项评估中，测量了最大收缩力。在20和100赫兹产生的肌力以强直力的增加值(IV)表示。在未刺激和刺激的胫前肌之间的比较中，治疗性电刺激(TES)可预防刺激水平的I型纤维(p&lt；.01)和2B型纤维(p&lt；.05)和100 Hz水平的2A型纤维(p&lt；.05)的萎缩。在100赫兹频率下，2A型和2B型非刺激肌和刺激肌的肌纤维直径有显著差异。100赫兹时肌力增加值显著大于20赫兹时(p&lt；0.05)。三种肌肉类型的高频和低频刺激纤维之间没有显著的组织学差异。结论：高频(100 Hz)刺激比不刺激或低频(20 Hz)刺激更有效地预防急性肌纤维萎缩，且高频刺激下肌力的增加值明显大于低频刺激，提示进一步的研究，包括高频刺激在急性脊髓损伤中的临床应用，值得进一步研究。

We evaluated the effects of high frequency electrical stimulation for preventing acute muscle atrophy after spinal cord transection in rats. The lesser fiber diameters from type 1, 2A and 2B muscle fibers were measured. In another assessment, maximal contraction force was measured. The muscle force produced at 20, and 100Hz was expressed as increasing values (IV) in tetanic force. In the comparison between non-stimulated and stimulated Tibialis Anterior (TA) muscles, the atrophy of type 1 fibers (p < .01) and type 2B fibers (p < .05) at both stimulated levels and of type 2A fibers at 100Hz level (p < .05) were preventedby therapeutic electrical stimulation (TES). There were significant differences in the size of muscle fiber diameter between non-stimulated and stimulated muscles at 100 Hz in type 2A and, markedly, in type 2B. The increasing value of muscle force was significantly greater at 100Hz than at 20Hz (p < .05). No significant histological differences were observed between high and low frequency stimulated fibers of any of the three muscle types. We concludes that acute atrophy of muscle fibers was more effectively prevented by high (100Hz) frequency stimulation than no or low (20Hz) frequency stimulation, and the increasing value of muscle force was significantly greater at high frequency stimulation than low frequency stimulation, suggesting that future studies, including the clinical application of high frequency stimulation to acute spinal cord injury, should be conducted.