Studies on the mechanisms of sensory retinal adhesion, its breakdown and reconstruction

对连续110眼特发性黄斑裂孔玻璃体切除术的效果进行了研究。井眼闭合率达90%。在兔眼视网膜实验中，感觉视网膜和RPE的早期附着对闭合至关重要，胶质细胞和RPE细胞起着重要作用。18眼出现视野缺损，均位于输液管对侧。这种视野缺损的发生率受输注气压的强烈影响。评价了兔眼气压对视网膜的损伤。扫描电镜观察到在输液管的对面有明显的视网膜病变。内限制膜常被剥离，暴露其下的神经纤维层。我们认为视野缺损的原因是机械性视网膜损伤。眼底变化是进行性的，因此在随访的几年中检查视野缺损的眼睛是很重要的。

We studied the result s of vitrectomy for consecutive 110 eyes with idiopathic macular hole. Closure of hole was achieved in 90%. In experimental retinal hohe of rabbits eyes, early attachment of sensory retina and RPE was essential for closure, and glial and RPE cells played an important roles. Eighteen eyes showed visual field defects, which was always located contralateral to the infusion cannula. The incidence of this visual field defect was influenced strongly by the infusion air pressure. The retinal damage by air pressure was evaluated in rabbit eyes. Sharply demarcated retinal lesions were observed at the opposite side from the infusion cannula with SEM. The internal limitimg membrane was often detached, and the underlying nerve fiber layer was exposed. We concluded the cause of visual field defect was mechanical retinal damage by infusion air pressure. The fundus changes were progressive, so it is important to examine eyes with visual field defect for a follow-up period of several years.