Studies on the mechanisms of sensory retinal adhesion, its breakdown and reconstruction

感觉性视网膜粘连及其破坏与重建机制的研究

• 批准号: 11671746
• 负责人: NEGI Akira
• 金额: $ 1.02万
• 依托单位: Kobe University (2000-2001)Kumamoto University (1999)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671746/
• 关键词: RETINA; VITREOUS; MACULA; MACULAR HOLE; RETINAL DETACHMENT; INTERNAL LIMITTING MEMBRANE; VISUAL FIELD DEFECT; 視野狭窄; 人工的後部硝子体剥離; 硝子体手術; 液空気置換; 実験的網膜剥離

We studied the result s of vitrectomy for consecutive 110 eyes with idiopathic macular hole. Closure of hole was achieved in 90%. In experimental retinal hohe of rabbits eyes, early attachment of sensory retina and RPE was essential for closure, and glial and RPE cells played an important roles. Eighteen eyes showed visual field defects, which was always located contralateral to the infusion cannula. The incidence of this visual field defect was influenced strongly by the infusion air pressure. The retinal damage by air pressure was evaluated in rabbit eyes. Sharply demarcated retinal lesions were observed at the opposite side from the infusion cannula with SEM. The internal limitimg membrane was often detached, and the underlying nerve fiber layer was exposed. We concluded the cause of visual field defect was mechanical retinal damage by infusion air pressure. The fundus changes were progressive, so it is important to examine eyes with visual field defect for a follow-up period of several years.

本文对110眼特发性黄斑裂孔行玻璃体切除术的结果进行了分析。孔闭合率90%。在兔眼实验性视网膜裂孔中，感觉视网膜和RPE的早期附着是关闭的必要条件，胶质细胞和RPE细胞起重要作用。18只眼出现视野缺损，均位于输注套管对侧。这种视野缺损的发生率受到输注气压的强烈影响。采用兔眼评价气压对视网膜的损伤。用SEM在输注套管的对侧观察到界限清晰的视网膜病变。内界膜常脱落，暴露神经纤维层。我们认为，视野缺损的原因是灌注气压造成的机械性视网膜损伤。眼底改变是渐进性的，因此对有视野缺损的眼睛进行数年的追踪检查是很重要的。

项目成果

HASUHURA T: "Retinal damage by air infusion during vitrectomy in rabbit eye."Invest Ophthlalmol Vis Sci. 41・13. 4300-4304 (2000)

HASUHURA T：“兔眼玻璃体切除术中空气注入造成的视网膜损伤”，Invest Ophthlalmol Vis Sci 41・13（2000）。

Yamana T: "The processs of closure of experimental retinal holes in rabbit eyes"Graefe's Arch Clin Exp Ophthalmol. 238. 81-87 (2000)

Yamana T：“兔眼实验性视网膜孔的闭合过程”Graefes Arch Clin Exp Ophamol。

Hasumura T: "Retinal damage by air infusion during vitrectomy in rabbit eyes"Invest Ophthalmol Vis Sci. 41. 4300-4304 (2000)

Hasumura T：“兔眼玻璃体切除术中空气注入造成的视网膜损伤”Invest Ophasemol Vis Sci。

Yonemura N: "Fundus changes corresponding to visual field defects after vitrectomy for macular hole"Ophthalmology. 108. 1638-1643 (2001)

米村 N：“黄斑裂孔玻璃体切除术后与视野缺损相对应的眼底变化”眼科。

T.Hasumura,N.Yonemura,A.Hirata,Y.Murata,A.Negi: "Retinal damage by fluid-air exchage during vitreous surgery in rabbits"Investigative Ophthalmology & Visual Science. 40・4. S943 (1999)

T. Hasumura、N. Yonemura、A. Hirata、Y. Murata、A. Negi：“兔子玻璃体手术期间液体-空气交换造成的视网膜损伤”调查眼科与视觉科学 40・4。